Adverse systemic reaction to benznidazole
Abstract Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benz...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100145&lng=en&tlng=en |
| _version_ | 1818534521044205568 |
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| author | María Verónica Pacheco Coronel Laura Oriente Frutos Eva Calabuig Muñoz Diana Kury Valle Dolores Hernández Fernández de Rojas |
| author_facet | María Verónica Pacheco Coronel Laura Oriente Frutos Eva Calabuig Muñoz Diana Kury Valle Dolores Hernández Fernández de Rojas |
| author_sort | María Verónica Pacheco Coronel |
| collection | DOAJ |
| description | Abstract Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benznidazole for CD in indeterminate chronic phase, presented with fever, skin lesions, digestive symptoms, general malaise, and laboratory abnormalities. After the discontinuation of benznidazole and, the intake of antihistamines and systemic corticosteroids, the patient presented a complete resolution of the symptoms. Optimization of dose strategies and development of more effective, and better-tolerated drugs is advisable. |
| first_indexed | 2024-12-11T18:12:43Z |
| format | Article |
| id | doaj.art-7b0e4c174ec5409eb23ece7e27e9e4c2 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-11T18:12:43Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-7b0e4c174ec5409eb23ece7e27e9e4c22022-12-22T00:55:31ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984950114514710.1590/0037-8682-0071-2016S0037-86822017000100145Adverse systemic reaction to benznidazoleMaría Verónica Pacheco CoronelLaura Oriente FrutosEva Calabuig MuñozDiana Kury ValleDolores Hernández Fernández de RojasAbstract Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benznidazole for CD in indeterminate chronic phase, presented with fever, skin lesions, digestive symptoms, general malaise, and laboratory abnormalities. After the discontinuation of benznidazole and, the intake of antihistamines and systemic corticosteroids, the patient presented a complete resolution of the symptoms. Optimization of dose strategies and development of more effective, and better-tolerated drugs is advisable.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100145&lng=en&tlng=enAdverse drug reactionBenznidazoleChagas disease |
| spellingShingle | María Verónica Pacheco Coronel Laura Oriente Frutos Eva Calabuig Muñoz Diana Kury Valle Dolores Hernández Fernández de Rojas Adverse systemic reaction to benznidazole Revista da Sociedade Brasileira de Medicina Tropical Adverse drug reaction Benznidazole Chagas disease |
| title | Adverse systemic reaction to benznidazole |
| title_full | Adverse systemic reaction to benznidazole |
| title_fullStr | Adverse systemic reaction to benznidazole |
| title_full_unstemmed | Adverse systemic reaction to benznidazole |
| title_short | Adverse systemic reaction to benznidazole |
| title_sort | adverse systemic reaction to benznidazole |
| topic | Adverse drug reaction Benznidazole Chagas disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100145&lng=en&tlng=en |
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