The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma

The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma

BackgroundDespite the significant progress in the treatment of multiple myeloma (MM), the disease remains untreatable and its cure is still an unmet clinical need. Neoplastic transformation in MM is initiated in the germinal centers (GCs) of secondary lymphoid tissue (SLT) where B cells experience e...

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Bibliographic Details
Main Authors: Nesreen Amer Ramadan Aly, Samia Rizk, Azza Aboul Enein, Nermeen El Desoukey, Hamdy Zawam, Manzoor Ahmed, Mohey Eldin El Shikh, Costantino Pitzalis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
SPARC
bone marrow
follicular dendritic cells
germinal center reactions
tumor microenvironments
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1009993/full

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