Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family
Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01591/full |
| _version_ | 1818962779546058752 |
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| author | Evelyn Lara Evelyn Lara Jesenia Acurio Jesenia Acurio José Leon José Leon Jeffrey Penny Pablo Torres-Vergara Pablo Torres-Vergara Carlos Escudero Carlos Escudero Carlos Escudero |
| author_facet | Evelyn Lara Evelyn Lara Jesenia Acurio Jesenia Acurio José Leon José Leon Jeffrey Penny Pablo Torres-Vergara Pablo Torres-Vergara Carlos Escudero Carlos Escudero Carlos Escudero |
| author_sort | Evelyn Lara |
| collection | DOAJ |
| description | Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental alterations in the children of preeclamptic pregnancies result from impaired angiogenesis. The pro-angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key regulators of both vascular and neurological development, and it has been widely demonstrated that umbilical blood of preeclamptic pregnancies contains high levels of soluble VEGF receptor type 1 (sFlt-1), a decoy receptor of VEGF. As a consequence, this anti-angiogenic state could lead to long-lasting neurological outcomes. In this non-systematic review, we propose that alterations in the circulating concentrations of VEGF, PlGF, and sFlt-1 in preeclamptic pregnancies will affect both fetal cerebrovascular function and neurodevelopment, which in turn may cause cognitive alterations in post-natal life. |
| first_indexed | 2024-12-20T12:34:45Z |
| format | Article |
| id | doaj.art-7b102f5f03c141e4953c927ae3dbeb17 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T12:34:45Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7b102f5f03c141e4953c927ae3dbeb172022-12-21T19:40:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-11-01910.3389/fphys.2018.01591410831Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF FamilyEvelyn Lara0Evelyn Lara1Jesenia Acurio2Jesenia Acurio3José Leon4José Leon5Jeffrey Penny6Pablo Torres-Vergara7Pablo Torres-Vergara8Carlos Escudero9Carlos Escudero10Carlos Escudero11Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, ChileGroup of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, ChileVascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, ChileGroup of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, ChileVascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, ChileGroup of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, ChileDivision of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomGroup of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, ChileDepartment of Pharmacy, Faculty of Pharmacy, Universidad de Concepción, Concepción, ChileVascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, ChileGroup of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, ChileRed Iberoamericana de alteraciones Vasculares Asociadas a TRastornos del EMbarazo (RIVA-TREM), Chillán, ChileEvidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental alterations in the children of preeclamptic pregnancies result from impaired angiogenesis. The pro-angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key regulators of both vascular and neurological development, and it has been widely demonstrated that umbilical blood of preeclamptic pregnancies contains high levels of soluble VEGF receptor type 1 (sFlt-1), a decoy receptor of VEGF. As a consequence, this anti-angiogenic state could lead to long-lasting neurological outcomes. In this non-systematic review, we propose that alterations in the circulating concentrations of VEGF, PlGF, and sFlt-1 in preeclamptic pregnancies will affect both fetal cerebrovascular function and neurodevelopment, which in turn may cause cognitive alterations in post-natal life.https://www.frontiersin.org/article/10.3389/fphys.2018.01591/fullpreeclampsiaangiogenesisneurovascularneurocognitivevascular endothelial growth factorplacental growth factor |
| spellingShingle | Evelyn Lara Evelyn Lara Jesenia Acurio Jesenia Acurio José Leon José Leon Jeffrey Penny Pablo Torres-Vergara Pablo Torres-Vergara Carlos Escudero Carlos Escudero Carlos Escudero Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family Frontiers in Physiology preeclampsia angiogenesis neurovascular neurocognitive vascular endothelial growth factor placental growth factor |
| title | Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family |
| title_full | Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family |
| title_fullStr | Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family |
| title_full_unstemmed | Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family |
| title_short | Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family |
| title_sort | are the cognitive alterations present in children born from preeclamptic pregnancies the result of impaired angiogenesis focus on the potential role of the vegf family |
| topic | preeclampsia angiogenesis neurovascular neurocognitive vascular endothelial growth factor placental growth factor |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01591/full |
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