TOX regulates T lymphocytes differentiation and its function in tumor
Thymocyte selection-associated high mobility group box protein (TOX) is expressed differently at all T lymphocytes development stages. Owing to more advanced scientific and technological means, including single-cell sequencing technology, heterogeneity of T lymphocytes and TOX has gradually been rev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.990419/full |
| _version_ | 1811157758069702656 |
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| author | Haiyue Niu Huaquan Wang |
| author_facet | Haiyue Niu Huaquan Wang |
| author_sort | Haiyue Niu |
| collection | DOAJ |
| description | Thymocyte selection-associated high mobility group box protein (TOX) is expressed differently at all T lymphocytes development stages. Owing to more advanced scientific and technological means, including single-cell sequencing technology, heterogeneity of T lymphocytes and TOX has gradually been revealed. Further exploration of such heterogeneity will help us comprehend the developmental stage and functional characteristics of T lymphocytes in greater detail. Emerging evidence supports its regulation not only in exhausting, but also in activating T lymphocytes, thereby verifying TOX heterogeneity. TOX can be used not only as a latent intervention target for tumor diseases and chronic infections, and a therapeutic strategy for autoimmune diseases, but also as a critical factor predicting the drug response and overall survival of patients with malignant tumors. |
| first_indexed | 2024-04-10T05:12:44Z |
| format | Article |
| id | doaj.art-7b11005ed66e43d3a2b5177cf16661ba |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T05:12:44Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7b11005ed66e43d3a2b5177cf16661ba2023-03-09T06:55:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.990419990419TOX regulates T lymphocytes differentiation and its function in tumorHaiyue NiuHuaquan WangThymocyte selection-associated high mobility group box protein (TOX) is expressed differently at all T lymphocytes development stages. Owing to more advanced scientific and technological means, including single-cell sequencing technology, heterogeneity of T lymphocytes and TOX has gradually been revealed. Further exploration of such heterogeneity will help us comprehend the developmental stage and functional characteristics of T lymphocytes in greater detail. Emerging evidence supports its regulation not only in exhausting, but also in activating T lymphocytes, thereby verifying TOX heterogeneity. TOX can be used not only as a latent intervention target for tumor diseases and chronic infections, and a therapeutic strategy for autoimmune diseases, but also as a critical factor predicting the drug response and overall survival of patients with malignant tumors.https://www.frontiersin.org/articles/10.3389/fimmu.2023.990419/fullTOXCD4CD8T-cell exhaustiontumor |
| spellingShingle | Haiyue Niu Huaquan Wang TOX regulates T lymphocytes differentiation and its function in tumor Frontiers in Immunology TOX CD4 CD8 T-cell exhaustion tumor |
| title | TOX regulates T lymphocytes differentiation and its function in tumor |
| title_full | TOX regulates T lymphocytes differentiation and its function in tumor |
| title_fullStr | TOX regulates T lymphocytes differentiation and its function in tumor |
| title_full_unstemmed | TOX regulates T lymphocytes differentiation and its function in tumor |
| title_short | TOX regulates T lymphocytes differentiation and its function in tumor |
| title_sort | tox regulates t lymphocytes differentiation and its function in tumor |
| topic | TOX CD4 CD8 T-cell exhaustion tumor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.990419/full |
| work_keys_str_mv | AT haiyueniu toxregulatestlymphocytesdifferentiationanditsfunctionintumor AT huaquanwang toxregulatestlymphocytesdifferentiationanditsfunctionintumor |