Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarker...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9507 |
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| author | Adrianna Radulska Iwona Pelikant-Małecka Kamila Jendernalik Iwona T. Dobrucki Leszek Kalinowski |
| author_facet | Adrianna Radulska Iwona Pelikant-Małecka Kamila Jendernalik Iwona T. Dobrucki Leszek Kalinowski |
| author_sort | Adrianna Radulska |
| collection | DOAJ |
| description | Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs. |
| first_indexed | 2024-03-11T03:05:43Z |
| format | Article |
| id | doaj.art-7b1377eafe904267ae51e0270b62e415 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:43Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7b1377eafe904267ae51e0270b62e4152023-11-18T08:00:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411950710.3390/ijms24119507Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical AspectsAdrianna Radulska0Iwona Pelikant-Małecka1Kamila Jendernalik2Iwona T. Dobrucki3Leszek Kalinowski4Department of Medical Laboratory Diagnostics—Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, PolandDepartment of Medical Laboratory Diagnostics—Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, PolandDepartment of Medical Laboratory Diagnostics—Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, PolandBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405N Mathews Ave., MC-251, Urbana, IL 61801, USADepartment of Medical Laboratory Diagnostics—Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, PolandSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs.https://www.mdpi.com/1422-0067/24/11/9507in vivo mouse modelspsoriasisproteomicsmetabolomics |
| spellingShingle | Adrianna Radulska Iwona Pelikant-Małecka Kamila Jendernalik Iwona T. Dobrucki Leszek Kalinowski Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects International Journal of Molecular Sciences in vivo mouse models psoriasis proteomics metabolomics |
| title | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
| title_full | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
| title_fullStr | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
| title_full_unstemmed | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
| title_short | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
| title_sort | proteomic and metabolomic changes in psoriasis preclinical and clinical aspects |
| topic | in vivo mouse models psoriasis proteomics metabolomics |
| url | https://www.mdpi.com/1422-0067/24/11/9507 |
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