Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review
Objectives: Hepatitis A is a viral liver disease whose prevalence is associated with low socio-economic and hygiene levels due to its faecal–oral transmission. Severity increases with age, and immunity is life-long. Decreased endemicity could result in increased age and severity of cases. A literatu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971217303387 |
| _version_ | 1818332570923827200 |
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| author | Marissa Gripenberg Naveena Aloysia D’Cor Maïna L’Azou Grenville Marsh Sophie Druelles Joshua Nealon |
| author_facet | Marissa Gripenberg Naveena Aloysia D’Cor Maïna L’Azou Grenville Marsh Sophie Druelles Joshua Nealon |
| author_sort | Marissa Gripenberg |
| collection | DOAJ |
| description | Objectives: Hepatitis A is a viral liver disease whose prevalence is associated with low socio-economic and hygiene levels due to its faecal–oral transmission. Severity increases with age, and immunity is life-long. Decreased endemicity could result in increased age and severity of cases. A literature review was conducted to describe changes in age-stratified hepatitis A seroprevalence in Asia Pacific countries from 1980 to 2016, and to identify gaps in the literature. The PRISMA guidelines were followed. Methods: The PubMed database was searched for studies on age-specific hepatitis A seroprevalence in 17 Asia Pacific countries. All studies published in the English language, reporting human hepatitis A seroprevalence levels in any age group, were included. Results: Seventy-three publications from 11 countries were identified. A trend of increasing age at first exposure over time was observed, particularly in developed countries such as Japan, Taiwan, Thailand, and Korea, suggesting a transition in terms of endemicity. Conclusions: Extensive gaps in the literature were identified between countries and year of publication, indicating the need for further research. Decreasing hepatitis A exposure and thus immunity conferred during childhood, may render older populations susceptible to infection. The public health and economic value of vaccination against hepatitis A should be assessed within this changing epidemiological context. Keywords: Hepatitis A, Seroprevalence, Asia Pacific, Epidemiology |
| first_indexed | 2024-12-13T13:37:51Z |
| format | Article |
| id | doaj.art-7b13a69b0b6a4d88b59e3cdb3a96ae11 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T13:37:51Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-7b13a69b0b6a4d88b59e3cdb3a96ae112022-12-21T23:43:42ZengElsevierInternational Journal of Infectious Diseases1201-97122018-03-01681317Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic reviewMarissa Gripenberg0Naveena Aloysia D’Cor1Maïna L’Azou2Grenville Marsh3Sophie Druelles4Joshua Nealon5Sanofi Pasteur Epidemiology and Health Economics, Asia and JPAC Regional Office, SingaporeClinical R&D, Shantha Biotechnics Pvt Ltd, Hyderabad, IndiaSanofi Pasteur, Health Economics and Outcomes Research, Lyon, FranceSanofi Pasteur Medical Department, Lyon, FranceSanofi Pasteur, Health Economics and Outcomes Research, Lyon, FranceSanofi Pasteur Epidemiology and Health Economics, Asia and JPAC Regional Office, Singapore; Corresponding author at: Sanofi Pasteur Regional Epidemiology and Health Economics. Asia and JPAC Regional Office, 38 Beach Road, #18-11, 189767, Singapore.Objectives: Hepatitis A is a viral liver disease whose prevalence is associated with low socio-economic and hygiene levels due to its faecal–oral transmission. Severity increases with age, and immunity is life-long. Decreased endemicity could result in increased age and severity of cases. A literature review was conducted to describe changes in age-stratified hepatitis A seroprevalence in Asia Pacific countries from 1980 to 2016, and to identify gaps in the literature. The PRISMA guidelines were followed. Methods: The PubMed database was searched for studies on age-specific hepatitis A seroprevalence in 17 Asia Pacific countries. All studies published in the English language, reporting human hepatitis A seroprevalence levels in any age group, were included. Results: Seventy-three publications from 11 countries were identified. A trend of increasing age at first exposure over time was observed, particularly in developed countries such as Japan, Taiwan, Thailand, and Korea, suggesting a transition in terms of endemicity. Conclusions: Extensive gaps in the literature were identified between countries and year of publication, indicating the need for further research. Decreasing hepatitis A exposure and thus immunity conferred during childhood, may render older populations susceptible to infection. The public health and economic value of vaccination against hepatitis A should be assessed within this changing epidemiological context. Keywords: Hepatitis A, Seroprevalence, Asia Pacific, Epidemiologyhttp://www.sciencedirect.com/science/article/pii/S1201971217303387 |
| spellingShingle | Marissa Gripenberg Naveena Aloysia D’Cor Maïna L’Azou Grenville Marsh Sophie Druelles Joshua Nealon Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review International Journal of Infectious Diseases |
| title | Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review |
| title_full | Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review |
| title_fullStr | Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review |
| title_full_unstemmed | Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review |
| title_short | Changing sero-epidemiology of hepatitis A in Asia Pacific countries: A systematic review |
| title_sort | changing sero epidemiology of hepatitis a in asia pacific countries a systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S1201971217303387 |
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