Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells
<i>Aphrocallistes vastus</i> lectin (AVL) is a C-type marine lectin derived from sponges. Our previous study demonstrated that oncolytic vaccinia virus carrying AVL (oncoVV-AVL) significantly enhanced the cytotoxicity of oncoVV in cervical cancer, colorectal cancer and hepatocellular car...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/11/667 |
| _version_ | 1827646220686852096 |
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| author | Xinnan Zheng Weizhe Xu Qi Ying Jiajun Ni Xiaoyuan Jia Yanrong Zhou Ting Ye Gongchu Li Kan Chen |
| author_facet | Xinnan Zheng Weizhe Xu Qi Ying Jiajun Ni Xiaoyuan Jia Yanrong Zhou Ting Ye Gongchu Li Kan Chen |
| author_sort | Xinnan Zheng |
| collection | DOAJ |
| description | <i>Aphrocallistes vastus</i> lectin (AVL) is a C-type marine lectin derived from sponges. Our previous study demonstrated that oncolytic vaccinia virus carrying AVL (oncoVV-AVL) significantly enhanced the cytotoxicity of oncoVV in cervical cancer, colorectal cancer and hepatocellular carcinoma through the activation of Ras/ERK, MAPK/ERK and PI3K/Akt signaling pathways. In this study, the inflammatory response induced by oncoVV-AVL in a hepatocellular carcinoma cell (HCC) model was investigated. The results showed that oncoVV-AVL increased the levels of inflammatory cytokines including IL-6, IL-8 and TNF-α through activating the AP-1 signaling pathway in HCC. This study provides novel insights into the utilization of lectin AVL in the field of cancer therapy. |
| first_indexed | 2024-03-09T18:54:52Z |
| format | Article |
| id | doaj.art-7b14c6fd6d784317bd7c266bed5cfca9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T18:54:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-7b14c6fd6d784317bd7c266bed5cfca92023-11-24T05:34:09ZengMDPI AGMarine Drugs1660-33972022-10-01201166710.3390/md20110667Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma CellsXinnan Zheng0Weizhe Xu1Qi Ying2Jiajun Ni3Xiaoyuan Jia4Yanrong Zhou5Ting Ye6Gongchu Li7Kan Chen8College of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, China<i>Aphrocallistes vastus</i> lectin (AVL) is a C-type marine lectin derived from sponges. Our previous study demonstrated that oncolytic vaccinia virus carrying AVL (oncoVV-AVL) significantly enhanced the cytotoxicity of oncoVV in cervical cancer, colorectal cancer and hepatocellular carcinoma through the activation of Ras/ERK, MAPK/ERK and PI3K/Akt signaling pathways. In this study, the inflammatory response induced by oncoVV-AVL in a hepatocellular carcinoma cell (HCC) model was investigated. The results showed that oncoVV-AVL increased the levels of inflammatory cytokines including IL-6, IL-8 and TNF-α through activating the AP-1 signaling pathway in HCC. This study provides novel insights into the utilization of lectin AVL in the field of cancer therapy.https://www.mdpi.com/1660-3397/20/11/667<i>Aphrocallistes vastus</i> lectinoncolytic vaccinia virusAP-1hepatocellular carcinoma |
| spellingShingle | Xinnan Zheng Weizhe Xu Qi Ying Jiajun Ni Xiaoyuan Jia Yanrong Zhou Ting Ye Gongchu Li Kan Chen Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells Marine Drugs <i>Aphrocallistes vastus</i> lectin oncolytic vaccinia virus AP-1 hepatocellular carcinoma |
| title | Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells |
| title_full | Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells |
| title_fullStr | Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells |
| title_full_unstemmed | Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells |
| title_short | Oncolytic Vaccinia Virus Carrying <i>Aphrocallistes vastus</i> Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells |
| title_sort | oncolytic vaccinia virus carrying i aphrocallistes vastus i lectin oncovv avl enhances inflammatory response in hepatocellular carcinoma cells |
| topic | <i>Aphrocallistes vastus</i> lectin oncolytic vaccinia virus AP-1 hepatocellular carcinoma |
| url | https://www.mdpi.com/1660-3397/20/11/667 |
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