One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy
Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/2/106 |
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| author | Erika Seki Kioshima Patrícia de Souza Bonfim de Mendonça Marcus de Melo Teixeira Isis Regina Grenier Capoci André Amaral Franciele Abigail Vilugron Rodrigues-Vendramini Bruna Lauton Simões Ana Karina Rodrigues Abadio Larissa Fernandes Matos Maria Sueli Soares Felipe |
| author_facet | Erika Seki Kioshima Patrícia de Souza Bonfim de Mendonça Marcus de Melo Teixeira Isis Regina Grenier Capoci André Amaral Franciele Abigail Vilugron Rodrigues-Vendramini Bruna Lauton Simões Ana Karina Rodrigues Abadio Larissa Fernandes Matos Maria Sueli Soares Felipe |
| author_sort | Erika Seki Kioshima |
| collection | DOAJ |
| description | Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of <i>Paracoccidioides</i>. In this context, <i>in silico</i> approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against <i>Paracoccidioides</i>. Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases. |
| first_indexed | 2024-03-09T06:04:25Z |
| format | Article |
| id | doaj.art-7b1595b2349f458aacc6fe6ce51cc55d |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T06:04:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-7b1595b2349f458aacc6fe6ce51cc55d2023-12-03T12:06:18ZengMDPI AGJournal of Fungi2309-608X2021-02-017210610.3390/jof7020106One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal TherapyErika Seki Kioshima0Patrícia de Souza Bonfim de Mendonça1Marcus de Melo Teixeira2Isis Regina Grenier Capoci3André Amaral4Franciele Abigail Vilugron Rodrigues-Vendramini5Bruna Lauton Simões6Ana Karina Rodrigues Abadio7Larissa Fernandes Matos8Maria Sueli Soares Felipe9Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, BrazilProgram in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, BrazilFaculty of Medicine, University of Brasília (UnB), Brasilia, Distrito Federal 70910-900, BrazilProgram in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, BrazilInstitute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74690-900, BrazilProgram in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, BrazilProgram in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, BrazilFaculty of Agricultural Social Sciences, Mato Grosso State University, Nova Mutum, Mato Grosso 78450-000, BrazilFaculty of Ceilandia, University of Brasília (UnB), Brasília, Distrito Federal 72220-275, BrazilProgram of Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brasília 70790-160, BrazilParacoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of <i>Paracoccidioides</i>. In this context, <i>in silico</i> approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against <i>Paracoccidioides</i>. Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases.https://www.mdpi.com/2309-608X/7/2/106genomicnew species discoverynew targetsantifungal |
| spellingShingle | Erika Seki Kioshima Patrícia de Souza Bonfim de Mendonça Marcus de Melo Teixeira Isis Regina Grenier Capoci André Amaral Franciele Abigail Vilugron Rodrigues-Vendramini Bruna Lauton Simões Ana Karina Rodrigues Abadio Larissa Fernandes Matos Maria Sueli Soares Felipe One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy Journal of Fungi genomic new species discovery new targets antifungal |
| title | One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy |
| title_full | One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy |
| title_fullStr | One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy |
| title_full_unstemmed | One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy |
| title_short | One Century of Study: What We Learned about <i>Paracoccidioides</i> and How This Pathogen Contributed to Advances in Antifungal Therapy |
| title_sort | one century of study what we learned about i paracoccidioides i and how this pathogen contributed to advances in antifungal therapy |
| topic | genomic new species discovery new targets antifungal |
| url | https://www.mdpi.com/2309-608X/7/2/106 |
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