Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues
Introduction: Despite its rarity, nail involvement in Langerhans cell histiocytosis (LCH) may show various clinical presentations. This study aims to show the roles of nail involvement in LCH patients as the diagnostic and prognostic clues. Case illustrations: We presented four cases of multisyst...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2020-06-01
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| Series: | JDVI (Journal of General Procedural Dermatology & Venereology Indonesia) |
| Subjects: | |
| Online Access: | http://www.jgenprodvi.ui.ac.id/index.php/jdvi/article/view/186/pdf |
| _version_ | 1818851049514991616 |
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| author | Sondang P. Sirait Rahadi Rihatmadja Rizky Lendl Prayogo Riesye Arisanty Gisca Meiviana Kuniaki Ohara |
| author_facet | Sondang P. Sirait Rahadi Rihatmadja Rizky Lendl Prayogo Riesye Arisanty Gisca Meiviana Kuniaki Ohara |
| author_sort | Sondang P. Sirait |
| collection | DOAJ |
| description | Introduction: Despite its rarity, nail involvement in Langerhans cell histiocytosis (LCH) may show various
clinical presentations. This study aims to show the roles of nail involvement in LCH patients as the diagnostic
and prognostic clues.
Case illustrations: We presented four cases of multisystem LCH in children which were already confirmed
by skin biopsy with various nail abnormalities. We were able to perform nail biopsy in two patients and
confirmed the nail involvement. Histopathological examination showed the infiltration of Langerhans cells
characterized by indented/reniform nuclei and CD1a expressions. All patients had high-risk organ
involvements.
Discussion: Langerhans cells may infiltrate the nail bed, proximal nail fold, and nail matrix. Further infiltration
may destruct the nail plate. Hypothetically, we suggest that the nail bed as the initial infiltration site of
Langerhans cells. The different sites of involvement lead to different clinical presentation. Nail abnormalities
may predict a poorer prognosis, as they mostly occur in patients with multisystem disease.
Conclusions: Nails should be routinely inspected in the suspicion of LCH. The presence of nail abnormalities
in LCH patients may predict a poorer prognosis. |
| first_indexed | 2024-12-19T06:58:51Z |
| format | Article |
| id | doaj.art-7b17837dd8bf46a4bd31b7816c5ad7e5 |
| institution | Directory Open Access Journal |
| issn | 2460-7991 2460-7991 |
| language | English |
| last_indexed | 2024-12-19T06:58:51Z |
| publishDate | 2020-06-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | JDVI (Journal of General Procedural Dermatology & Venereology Indonesia) |
| spelling | doaj.art-7b17837dd8bf46a4bd31b7816c5ad7e52022-12-21T20:31:28ZengUniversitas IndonesiaJDVI (Journal of General Procedural Dermatology & Venereology Indonesia)2460-79912460-79912020-06-0142919510.19100/jdvi.v4i2.186Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic CluesSondang P. Sirait0Rahadi Rihatmadja1Rizky Lendl Prayogo2Riesye Arisanty3Gisca Meiviana4Kuniaki Ohara5Departement of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital, JakartaDepartement of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital, JakartaDepartement of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital, JakartaDepartement of Anatomical Pathology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital, JakartaDepartement of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital, JakartaToranomon Hospital, Tokyo, JapanIntroduction: Despite its rarity, nail involvement in Langerhans cell histiocytosis (LCH) may show various clinical presentations. This study aims to show the roles of nail involvement in LCH patients as the diagnostic and prognostic clues. Case illustrations: We presented four cases of multisystem LCH in children which were already confirmed by skin biopsy with various nail abnormalities. We were able to perform nail biopsy in two patients and confirmed the nail involvement. Histopathological examination showed the infiltration of Langerhans cells characterized by indented/reniform nuclei and CD1a expressions. All patients had high-risk organ involvements. Discussion: Langerhans cells may infiltrate the nail bed, proximal nail fold, and nail matrix. Further infiltration may destruct the nail plate. Hypothetically, we suggest that the nail bed as the initial infiltration site of Langerhans cells. The different sites of involvement lead to different clinical presentation. Nail abnormalities may predict a poorer prognosis, as they mostly occur in patients with multisystem disease. Conclusions: Nails should be routinely inspected in the suspicion of LCH. The presence of nail abnormalities in LCH patients may predict a poorer prognosis.http://www.jgenprodvi.ui.ac.id/index.php/jdvi/article/view/186/pdfnaillangerhans cell histiocytosisdiagnosisprognosis |
| spellingShingle | Sondang P. Sirait Rahadi Rihatmadja Rizky Lendl Prayogo Riesye Arisanty Gisca Meiviana Kuniaki Ohara Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues JDVI (Journal of General Procedural Dermatology & Venereology Indonesia) nail langerhans cell histiocytosis diagnosis prognosis |
| title | Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues |
| title_full | Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues |
| title_fullStr | Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues |
| title_full_unstemmed | Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues |
| title_short | Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues |
| title_sort | nail involvement in langerhans cell histiocytosis diagnostic and prognostic clues |
| topic | nail langerhans cell histiocytosis diagnosis prognosis |
| url | http://www.jgenprodvi.ui.ac.id/index.php/jdvi/article/view/186/pdf |
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