Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers
Exposure to stress or traumatic events can lead to the development of depression and anxiety disorders. In addition to the debilitating consequences on mental health, patients with psychiatric disorders also suffer from autonomic imbalance, making them susceptible to a variety of medical disorders....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Psychology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00950/full |
| _version_ | 1818416865667448832 |
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| author | Susan K Wood, Phd |
| author_facet | Susan K Wood, Phd |
| author_sort | Susan K Wood, Phd |
| collection | DOAJ |
| description | Exposure to stress or traumatic events can lead to the development of depression and anxiety disorders. In addition to the debilitating consequences on mental health, patients with psychiatric disorders also suffer from autonomic imbalance, making them susceptible to a variety of medical disorders. Emerging evidence utilizing spectral analysis of heart rate variability (HRV), a reliable noninvasive measure of cardiovascular autonomic regulation, indicates that patients with depression and various anxiety disorders (i.e., panic, social, generalized anxiety disorders, and post traumatic stress disorder) are characterized by decreased HRV. Social stressors in rodents are ethologically relevant experimental stressors that recapitulate many of the dysfunctional behavioral and physiological changes that occur in psychological disorders. In this review, evidence from clinical studies and preclinical stress models identify putative biomarkers capable of precipitating the comorbidity between disorders of the mind and autonomic dysfunction. Specifically, the role of corticotropin releasing factor, neuropeptide Y and inflammation are investigated. The impetus for this review is to highlight stress-related biomarkers that may prove critical in the development of autonomic imbalance in stress -related psychiatric disorders. |
| first_indexed | 2024-12-14T11:57:41Z |
| format | Article |
| id | doaj.art-7b180cd5159740aa8f8dd1f8392ef0b1 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-14T11:57:41Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-7b180cd5159740aa8f8dd1f8392ef0b12022-12-21T23:02:04ZengFrontiers Media S.A.Frontiers in Psychology1664-10782014-08-01510.3389/fpsyg.2014.00950109128Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkersSusan K Wood, Phd0University of South Carolina School of MedicineExposure to stress or traumatic events can lead to the development of depression and anxiety disorders. In addition to the debilitating consequences on mental health, patients with psychiatric disorders also suffer from autonomic imbalance, making them susceptible to a variety of medical disorders. Emerging evidence utilizing spectral analysis of heart rate variability (HRV), a reliable noninvasive measure of cardiovascular autonomic regulation, indicates that patients with depression and various anxiety disorders (i.e., panic, social, generalized anxiety disorders, and post traumatic stress disorder) are characterized by decreased HRV. Social stressors in rodents are ethologically relevant experimental stressors that recapitulate many of the dysfunctional behavioral and physiological changes that occur in psychological disorders. In this review, evidence from clinical studies and preclinical stress models identify putative biomarkers capable of precipitating the comorbidity between disorders of the mind and autonomic dysfunction. Specifically, the role of corticotropin releasing factor, neuropeptide Y and inflammation are investigated. The impetus for this review is to highlight stress-related biomarkers that may prove critical in the development of autonomic imbalance in stress -related psychiatric disorders.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00950/fullAnxietyDepressionInflammationNeuropeptide YSocial IsolationHeart rate variability |
| spellingShingle | Susan K Wood, Phd Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers Frontiers in Psychology Anxiety Depression Inflammation Neuropeptide Y Social Isolation Heart rate variability |
| title | Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers |
| title_full | Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers |
| title_fullStr | Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers |
| title_full_unstemmed | Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers |
| title_short | Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers |
| title_sort | cardiac autonomic imbalance by social stress in rodents understanding putative biomarkers |
| topic | Anxiety Depression Inflammation Neuropeptide Y Social Isolation Heart rate variability |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00950/full |
| work_keys_str_mv | AT susankwoodphd cardiacautonomicimbalancebysocialstressinrodentsunderstandingputativebiomarkers |