Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARγ stimulation

Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARγ stimulation

<p>Abstract</p> <p>Background</p> <p>Type 2 diabetes mellitus (T2DM) is commonly associated with both microvascular and macrovascular complications and a strong correlation exists between glycaemic control and the incidence and progression of vascular complications. Pio...

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Bibliographic Details
Main Authors: Iuliano Luigi, De Angelis Giulia, Rizzo Paola, Pecorini Giovanni, Stigliano Egidio, Arena Vincenzo, Straface Giuseppe, Biscetti Federico, Ghirlanda Giovanni, Flex Andrea
Format: Article
Language:English
Published: BMC 2009-09-01
Series:Cardiovascular Diabetology
Online Access:http://www.cardiab.com/content/8/1/49

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