Design of human immunodeficiency virus-1 neutralizing peptides targeting CD4-binding site: An integrative computational biologics approach

Design of human immunodeficiency virus-1 neutralizing peptides targeting CD4-binding site: An integrative computational biologics approach

Peptide therapeutics have recently gained momentum in antiviral therapy due to their increased potency and cost-effectiveness. Interaction of the HIV-1 envelope gp120 with the host CD4 receptor is a critical step for viral entry, and therefore the CD4-binding site (CD4bs) of gp120 is a potential hot...

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Bibliographic Details
Main Authors: Sandhya Vivekanandan, Umashankar Vetrivel, Luke Elizabeth Hanna
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
HIV-1
peptide therapeutics
CD4-binding site
neutralizing peptides
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1036874/full

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