Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary
Background: Botulinum toxin A (BTX) and microwave thermolysis (MWT) represent 2 treatment modalities for axillary hyperhidrosis with different procedural and efficacy profiles. Objective: To compare long-term outcomes following BTX vs MWT treatment of axillary hyperhidrosis. Methods: A prospective,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | JAAD International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328724000099 |
| _version_ | 1797266431731040256 |
|---|---|
| author | Gabriela Lladó Grove, MD Katrine Togsverd-Bo, MD, PhD, DMSc Claus Zachariae, MD, PhD, DMSc Merete Haedersdal, MD, PhD, DMSc |
| author_facet | Gabriela Lladó Grove, MD Katrine Togsverd-Bo, MD, PhD, DMSc Claus Zachariae, MD, PhD, DMSc Merete Haedersdal, MD, PhD, DMSc |
| author_sort | Gabriela Lladó Grove, MD |
| collection | DOAJ |
| description | Background: Botulinum toxin A (BTX) and microwave thermolysis (MWT) represent 2 treatment modalities for axillary hyperhidrosis with different procedural and efficacy profiles. Objective: To compare long-term outcomes following BTX vs MWT treatment of axillary hyperhidrosis. Methods: A prospective, randomized, within-patient, controlled trial, treating axillary hyperhidrosis with contralateral BTX and MWT. Objective sweat measurement and patient-reported outcome measures for sweat and odor were collected at baseline, 6-month and 1-year follow-up (6M/1YFU). Hair reduction and patient treatment preference was also assessed. Results: Sweat reduction was significant (all P <.01) for both interventions throughout the study. Objectively, sweat reduction was equal at 1-year FU (ΔP =.4282), but greater for BTX than MWT at 6-month FU (ΔP =.0053). Subjective sweat assessment presented comparable efficacy (6MFU: ΔP =.4142, 1YFU: ΔP =.1025). Odor reduction was significant (all P <.01) following both interventions, whereas only sustaining for MWT (6MFU: ΔP =.6826, 1YFU: ΔP =.0098). Long-term, hair reduction was visible after MWT, but not BTX (ΔP ≤.0001), and MWT was preferred by the majority of patients (76%). Limitations: The intrinsic challenges in efficacy assessment. Conclusion: This study exhibited BTX and MWT with similar sweat reduction, but distinguishable odor and hair reduction at 1-year FU. These findings support individualized treatment approaches for axillary hyperhidrosis based on patient-specific symptoms and preferences. |
| first_indexed | 2024-04-25T01:00:35Z |
| format | Article |
| id | doaj.art-7b1acdeac33b4e9cba2f83b5531175cb |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-04-25T01:00:35Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-7b1acdeac33b4e9cba2f83b5531175cb2024-03-11T04:11:09ZengElsevierJAAD International2666-32872024-06-01159199Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule SummaryGabriela Lladó Grove, MD0Katrine Togsverd-Bo, MD, PhD, DMSc1Claus Zachariae, MD, PhD, DMSc2Merete Haedersdal, MD, PhD, DMSc3Department of Dermatology, Copenhagen University Hospital – Bispebjerg, Copenhagen, Denmark; Correspondence to: Gabriela Lladó Grove, MD, Department of Dermatology, Copenhagen University Hospital – Bispebjerg, Nielsine Nielsens Vej 17, building 9, 2nd floor, 2400 Copenhagen NV, Denmark.Department of Dermatology, Copenhagen University Hospital – Bispebjerg, Copenhagen, DenmarkDepartment of Dermatology, Copenhagen University Hospital – Gentofte, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkDepartment of Dermatology, Copenhagen University Hospital – Bispebjerg, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkBackground: Botulinum toxin A (BTX) and microwave thermolysis (MWT) represent 2 treatment modalities for axillary hyperhidrosis with different procedural and efficacy profiles. Objective: To compare long-term outcomes following BTX vs MWT treatment of axillary hyperhidrosis. Methods: A prospective, randomized, within-patient, controlled trial, treating axillary hyperhidrosis with contralateral BTX and MWT. Objective sweat measurement and patient-reported outcome measures for sweat and odor were collected at baseline, 6-month and 1-year follow-up (6M/1YFU). Hair reduction and patient treatment preference was also assessed. Results: Sweat reduction was significant (all P <.01) for both interventions throughout the study. Objectively, sweat reduction was equal at 1-year FU (ΔP =.4282), but greater for BTX than MWT at 6-month FU (ΔP =.0053). Subjective sweat assessment presented comparable efficacy (6MFU: ΔP =.4142, 1YFU: ΔP =.1025). Odor reduction was significant (all P <.01) following both interventions, whereas only sustaining for MWT (6MFU: ΔP =.6826, 1YFU: ΔP =.0098). Long-term, hair reduction was visible after MWT, but not BTX (ΔP ≤.0001), and MWT was preferred by the majority of patients (76%). Limitations: The intrinsic challenges in efficacy assessment. Conclusion: This study exhibited BTX and MWT with similar sweat reduction, but distinguishable odor and hair reduction at 1-year FU. These findings support individualized treatment approaches for axillary hyperhidrosis based on patient-specific symptoms and preferences.http://www.sciencedirect.com/science/article/pii/S2666328724000099botulinum toxinbromhidrosishyperhidrosisindividualized treatmentmicrowave thermolysisosmidrosis |
| spellingShingle | Gabriela Lladó Grove, MD Katrine Togsverd-Bo, MD, PhD, DMSc Claus Zachariae, MD, PhD, DMSc Merete Haedersdal, MD, PhD, DMSc Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary JAAD International botulinum toxin bromhidrosis hyperhidrosis individualized treatment microwave thermolysis osmidrosis |
| title | Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary |
| title_full | Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary |
| title_fullStr | Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary |
| title_full_unstemmed | Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary |
| title_short | Botulinum toxin A versus microwave thermolysis for primary axillary hyperhidrosis: A randomized controlled trialCapsule Summary |
| title_sort | botulinum toxin a versus microwave thermolysis for primary axillary hyperhidrosis a randomized controlled trialcapsule summary |
| topic | botulinum toxin bromhidrosis hyperhidrosis individualized treatment microwave thermolysis osmidrosis |
| url | http://www.sciencedirect.com/science/article/pii/S2666328724000099 |
| work_keys_str_mv | AT gabrielalladogrovemd botulinumtoxinaversusmicrowavethermolysisforprimaryaxillaryhyperhidrosisarandomizedcontrolledtrialcapsulesummary AT katrinetogsverdbomdphddmsc botulinumtoxinaversusmicrowavethermolysisforprimaryaxillaryhyperhidrosisarandomizedcontrolledtrialcapsulesummary AT clauszachariaemdphddmsc botulinumtoxinaversusmicrowavethermolysisforprimaryaxillaryhyperhidrosisarandomizedcontrolledtrialcapsulesummary AT meretehaedersdalmdphddmsc botulinumtoxinaversusmicrowavethermolysisforprimaryaxillaryhyperhidrosisarandomizedcontrolledtrialcapsulesummary |