Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

Abstract Background Internal tandem duplications in the FLT3 gene, termed FLT3-ITDs, are useful molecular markers in acute myeloid leukemia (AML) for patient risk stratification and follow-up. FLT3-ITDs are increasingly screened through high-throughput sequencing (HTS) raising the need for robust an...

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Bibliographic Details
Main Authors: Augustin Boudry, Sasha Darmon, Nicolas Duployez, Martin Figeac, Sandrine Geffroy, Maxime Bucci, Karine Celli-Lebras, Matthieu Duchmann, Romane Joudinaud, Laurène Fenwarth, Olivier Nibourel, Laure Goursaud, Raphael Itzykson, Hervé Dombret, Mathilde Hunault, Claude Preudhomme, Mikaël Salson
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Bioinformatics
Subjects:
Sequence analysis
High-throughput sequencing
Alignment-free
Cancer
Online Access:https://doi.org/10.1186/s12859-022-04983-6

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