Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection
Objective: Management of cornual gestational trophoblastic neoplasia (GTN) has never been reported. Here, we describe the first case of cornual GTN. Case Report: A 32-year-old woman was diagnosed with left cornual GTN after evacuation of a complete mole. Laparoscopic cornuostomy was performed with i...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455917300311 |
| _version_ | 1818586606904279040 |
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| author | Pei-Ling Chen Jie-Yang Jhuang Ho-Hsiung Lin Sheng-Mou Hsiao |
| author_facet | Pei-Ling Chen Jie-Yang Jhuang Ho-Hsiung Lin Sheng-Mou Hsiao |
| author_sort | Pei-Ling Chen |
| collection | DOAJ |
| description | Objective: Management of cornual gestational trophoblastic neoplasia (GTN) has never been reported. Here, we describe the first case of cornual GTN.
Case Report: A 32-year-old woman was diagnosed with left cornual GTN after evacuation of a complete mole. Laparoscopic cornuostomy was performed with intramural vasopression injection and barbed sutures. Histopathology revealed hydropic chorionic villi. Complete hydatidiform mole was diagnosed, and treated with adjuvant methotrexate, to address the poor decline of β-human chorionic gonadotropin levels during follow-up. The β- human chorionic gonadotropin levels declined to < 1 mIU/mL 9 months after cornuostomy. She successfully conceived 16 months after cornuostomy, and underwent cesarean section at 37 gestational weeks due to concomitant severe preeclampsia.
Conclusion: Cornual GTN can be successfully managed with laparoscopic cornuostomy and adjuvant methotrexate. |
| first_indexed | 2024-12-16T08:55:39Z |
| format | Article |
| id | doaj.art-7b1dee406a16438fb8cb1171e429af93 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-16T08:55:39Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-7b1dee406a16438fb8cb1171e429af932022-12-21T22:37:18ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592017-04-0156226126310.1016/j.tjog.2016.09.008Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injectionPei-Ling Chen0Jie-Yang Jhuang1Ho-Hsiung Lin2Sheng-Mou Hsiao3Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, TaiwanDepartment of Pathology, Far Eastern Memorial Hospital, New Taipei City, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, TaiwanObjective: Management of cornual gestational trophoblastic neoplasia (GTN) has never been reported. Here, we describe the first case of cornual GTN. Case Report: A 32-year-old woman was diagnosed with left cornual GTN after evacuation of a complete mole. Laparoscopic cornuostomy was performed with intramural vasopression injection and barbed sutures. Histopathology revealed hydropic chorionic villi. Complete hydatidiform mole was diagnosed, and treated with adjuvant methotrexate, to address the poor decline of β-human chorionic gonadotropin levels during follow-up. The β- human chorionic gonadotropin levels declined to < 1 mIU/mL 9 months after cornuostomy. She successfully conceived 16 months after cornuostomy, and underwent cesarean section at 37 gestational weeks due to concomitant severe preeclampsia. Conclusion: Cornual GTN can be successfully managed with laparoscopic cornuostomy and adjuvant methotrexate.http://www.sciencedirect.com/science/article/pii/S1028455917300311gestational trophoblastic diseasehydatidiform molemethotrexatepelvic laparoscopypregnancy |
| spellingShingle | Pei-Ling Chen Jie-Yang Jhuang Ho-Hsiung Lin Sheng-Mou Hsiao Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection Taiwanese Journal of Obstetrics & Gynecology gestational trophoblastic disease hydatidiform mole methotrexate pelvic laparoscopy pregnancy |
| title | Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection |
| title_full | Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection |
| title_fullStr | Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection |
| title_full_unstemmed | Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection |
| title_short | Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection |
| title_sort | successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection |
| topic | gestational trophoblastic disease hydatidiform mole methotrexate pelvic laparoscopy pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S1028455917300311 |
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