Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study
According to the revision of the FIGO 2018 staging system, cervical cancer with pelvic lymph node metastases was changed to stage IIIC1. We retrospectively analyzed the prognosis and complications of locally resectable (classified as T1/T2 by TNM classification of the Union for International Cancer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/11/5/632 |
| _version_ | 1797615315378503680 |
|---|---|
| author | Yoko Kashima Kosuke Murakami Chiho Miyagawa Hisamitsu Takaya Yasushi Kotani Hidekatsu Nakai Noriomi Matsumura |
| author_facet | Yoko Kashima Kosuke Murakami Chiho Miyagawa Hisamitsu Takaya Yasushi Kotani Hidekatsu Nakai Noriomi Matsumura |
| author_sort | Yoko Kashima |
| collection | DOAJ |
| description | According to the revision of the FIGO 2018 staging system, cervical cancer with pelvic lymph node metastases was changed to stage IIIC1. We retrospectively analyzed the prognosis and complications of locally resectable (classified as T1/T2 by TNM classification of the Union for International Cancer Control) stage IIIC1 cervical cancer. A total of 43 patients were divided into three groups: surgery with chemotherapy (CT) (ope+CT group) (T1; n = 7, T2; n = 16), surgery followed by concurrent chemoradiotherapy (CCRT), or radiotherapy (RT) (ope+RT group) (T1; n = 5, T2; n = 9), and CCRT or RT alone (RT group) (T1; n = 0, T2; n = 6). In T1 patients, recurrence was observed in three patients, but there was no difference among the treatment groups, and no patients died. In contrast, in T2 patients, recurrence and death were observed in nine patients (8 in ope+CT; 1 in ope+RT), and recurrence-free survival and overall survival were lower in the ope+CT group (<i>p</i> = 0.02 and 0.04, respectively). Lymphedema and dysuria were more common in the ope+RT group. A randomized controlled trial comparing CT and CCRT as an adjuvant therapy after surgery in T1/T2 patients, including those with pelvic lymph node metastases, is currently underway. However, our data suggest that performing CT alone after surgery in T2N1 patients is likely to worsen the prognosis. |
| first_indexed | 2024-03-11T07:24:36Z |
| format | Article |
| id | doaj.art-7b1fdb5bc96542babb570c290aec9d24 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T07:24:36Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-7b1fdb5bc96542babb570c290aec9d242023-11-17T07:42:31ZengMDPI AGHealthcare2227-90322023-02-0111563210.3390/healthcare11050632Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution StudyYoko Kashima0Kosuke Murakami1Chiho Miyagawa2Hisamitsu Takaya3Yasushi Kotani4Hidekatsu Nakai5Noriomi Matsumura6Department of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Sayama 589-8511, JapanAccording to the revision of the FIGO 2018 staging system, cervical cancer with pelvic lymph node metastases was changed to stage IIIC1. We retrospectively analyzed the prognosis and complications of locally resectable (classified as T1/T2 by TNM classification of the Union for International Cancer Control) stage IIIC1 cervical cancer. A total of 43 patients were divided into three groups: surgery with chemotherapy (CT) (ope+CT group) (T1; n = 7, T2; n = 16), surgery followed by concurrent chemoradiotherapy (CCRT), or radiotherapy (RT) (ope+RT group) (T1; n = 5, T2; n = 9), and CCRT or RT alone (RT group) (T1; n = 0, T2; n = 6). In T1 patients, recurrence was observed in three patients, but there was no difference among the treatment groups, and no patients died. In contrast, in T2 patients, recurrence and death were observed in nine patients (8 in ope+CT; 1 in ope+RT), and recurrence-free survival and overall survival were lower in the ope+CT group (<i>p</i> = 0.02 and 0.04, respectively). Lymphedema and dysuria were more common in the ope+RT group. A randomized controlled trial comparing CT and CCRT as an adjuvant therapy after surgery in T1/T2 patients, including those with pelvic lymph node metastases, is currently underway. However, our data suggest that performing CT alone after surgery in T2N1 patients is likely to worsen the prognosis.https://www.mdpi.com/2227-9032/11/5/632cervical cancerchemotherapyconcurrent chemoradiotherapylymph nodesurgeryradiotherapy |
| spellingShingle | Yoko Kashima Kosuke Murakami Chiho Miyagawa Hisamitsu Takaya Yasushi Kotani Hidekatsu Nakai Noriomi Matsumura Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study Healthcare cervical cancer chemotherapy concurrent chemoradiotherapy lymph node surgery radiotherapy |
| title | Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study |
| title_full | Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study |
| title_fullStr | Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study |
| title_full_unstemmed | Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study |
| title_short | Treatment for Locally Resectable Stage IIIC1 Cervical Cancer: A Retrospective, Single-Institution Study |
| title_sort | treatment for locally resectable stage iiic1 cervical cancer a retrospective single institution study |
| topic | cervical cancer chemotherapy concurrent chemoradiotherapy lymph node surgery radiotherapy |
| url | https://www.mdpi.com/2227-9032/11/5/632 |
| work_keys_str_mv | AT yokokashima treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy AT kosukemurakami treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy AT chihomiyagawa treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy AT hisamitsutakaya treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy AT yasushikotani treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy AT hidekatsunakai treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy AT noriomimatsumura treatmentforlocallyresectablestageiiic1cervicalcanceraretrospectivesingleinstitutionstudy |