Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study
Type 2 diabetes (T2D) is a complex metabolic derangement that has a strong genetic basis. There is substantial population-specificity in the association of genetic variants with T2D. The Indian urban Sindhi population is at a high risk of T2D. The genetic basis of T2D in this population is unknown....
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1298 |
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| author | Kanchan V. Pipal Manju Mamtani Ashwini A. Patel Sujeet G. Jaiswal Manisha T. Jaisinghani Hemant Kulkarni |
| author_facet | Kanchan V. Pipal Manju Mamtani Ashwini A. Patel Sujeet G. Jaiswal Manisha T. Jaisinghani Hemant Kulkarni |
| author_sort | Kanchan V. Pipal |
| collection | DOAJ |
| description | Type 2 diabetes (T2D) is a complex metabolic derangement that has a strong genetic basis. There is substantial population-specificity in the association of genetic variants with T2D. The Indian urban Sindhi population is at a high risk of T2D. The genetic basis of T2D in this population is unknown. We interrogated 28 pooled whole blood genomes of 1402 participants from the Diabetes In Sindhi Families In Nagpur (DISFIN) study using Illumina’s Global Screening Array. From a total of 608,550 biallelic variants, 140 were significantly associated with T2D after adjusting for comorbidities, batch effects, pooling error, kinship status and pooling variation in a random effects multivariable logistic regression framework. Of the 102 well-characterized genes that these variants mapped onto, 70 genes have been previously reported to be associated with T2D to varying degrees with known functional relevance. Excluding open reading frames, intergenic non-coding elements and pseudogenes, our study identified 22 novel candidate genes in the Sindhi population studied. Our study thus points to the potential, interesting candidate genes associated with T2D in an ethnically endogamous population. These candidate genes need to be fully investigated in future studies. |
| first_indexed | 2024-03-09T13:23:25Z |
| format | Article |
| id | doaj.art-7b1fdbe9cb7946cb91e26995921aa113 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T13:23:25Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-7b1fdbe9cb7946cb91e26995921aa1132023-11-30T21:26:59ZengMDPI AGGenes2073-44252022-07-01138129810.3390/genes13081298Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association StudyKanchan V. Pipal0Manju Mamtani1Ashwini A. Patel2Sujeet G. Jaiswal3Manisha T. Jaisinghani4Hemant Kulkarni5Lata Medical Research Foundation, Nagpur 440002, IndiaLata Medical Research Foundation, Nagpur 440002, IndiaLata Medical Research Foundation, Nagpur 440002, IndiaLata Medical Research Foundation, Nagpur 440002, IndiaLata Medical Research Foundation, Nagpur 440002, IndiaLata Medical Research Foundation, Nagpur 440002, IndiaType 2 diabetes (T2D) is a complex metabolic derangement that has a strong genetic basis. There is substantial population-specificity in the association of genetic variants with T2D. The Indian urban Sindhi population is at a high risk of T2D. The genetic basis of T2D in this population is unknown. We interrogated 28 pooled whole blood genomes of 1402 participants from the Diabetes In Sindhi Families In Nagpur (DISFIN) study using Illumina’s Global Screening Array. From a total of 608,550 biallelic variants, 140 were significantly associated with T2D after adjusting for comorbidities, batch effects, pooling error, kinship status and pooling variation in a random effects multivariable logistic regression framework. Of the 102 well-characterized genes that these variants mapped onto, 70 genes have been previously reported to be associated with T2D to varying degrees with known functional relevance. Excluding open reading frames, intergenic non-coding elements and pseudogenes, our study identified 22 novel candidate genes in the Sindhi population studied. Our study thus points to the potential, interesting candidate genes associated with T2D in an ethnically endogamous population. These candidate genes need to be fully investigated in future studies.https://www.mdpi.com/2073-4425/13/8/1298type 2 diabetesgenome-wide association studyethnicity |
| spellingShingle | Kanchan V. Pipal Manju Mamtani Ashwini A. Patel Sujeet G. Jaiswal Manisha T. Jaisinghani Hemant Kulkarni Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study Genes type 2 diabetes genome-wide association study ethnicity |
| title | Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study |
| title_full | Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study |
| title_fullStr | Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study |
| title_full_unstemmed | Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study |
| title_short | Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study |
| title_sort | susceptibility loci for type 2 diabetes in the ethnically endogamous indian sindhi population a pooled blood genome wide association study |
| topic | type 2 diabetes genome-wide association study ethnicity |
| url | https://www.mdpi.com/2073-4425/13/8/1298 |
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