The amygdala is not necessary for the familiarity aspect of recognition memory
Abstract Dual-process accounts of item recognition posit two memory processes: slow but detailed recollection, and quick but vague familiarity. It has been proposed, based on prior rodent work, that the amygdala is critical for the familiarity aspect of item recognition. Here, we evaluated this prop...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43906-8 |
| _version_ | 1797397881920946176 |
|---|---|
| author | Benjamin M. Basile Vincent D. Costa Jamie L. Schafroth Chloe L. Karaskiewicz Daniel R. Lucas Elisabeth A. Murray |
| author_facet | Benjamin M. Basile Vincent D. Costa Jamie L. Schafroth Chloe L. Karaskiewicz Daniel R. Lucas Elisabeth A. Murray |
| author_sort | Benjamin M. Basile |
| collection | DOAJ |
| description | Abstract Dual-process accounts of item recognition posit two memory processes: slow but detailed recollection, and quick but vague familiarity. It has been proposed, based on prior rodent work, that the amygdala is critical for the familiarity aspect of item recognition. Here, we evaluated this proposal in male rhesus monkeys (Macaca mulatta) with selective bilateral excitotoxic amygdala damage. We used four established visual memory tests designed to assess different aspects of familiarity, all administered on touchscreen computers. Specifically, we assessed monkeys’ tendencies to make low-latency false alarms, to make false alarms to recently seen lures, to produce curvilinear ROC curves, and to discriminate stimuli based on repetition across days. Three of the four tests showed no familiarity impairment and the fourth was explained by a deficit in reward processing. Consistent with this, amygdala damage did produce an anticipated deficit in reward processing in a three-arm-bandit gambling task, verifying the effectiveness of the lesions. Together, these results contradict prior rodent work and suggest that the amygdala is not critical for the familiarity aspect of item recognition. |
| first_indexed | 2024-03-09T01:17:38Z |
| format | Article |
| id | doaj.art-7b2787fbe8d94c00864e943842e5fd1e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-09T01:17:38Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7b2787fbe8d94c00864e943842e5fd1e2023-12-10T12:23:48ZengNature PortfolioNature Communications2041-17232023-12-0114111410.1038/s41467-023-43906-8The amygdala is not necessary for the familiarity aspect of recognition memoryBenjamin M. Basile0Vincent D. Costa1Jamie L. Schafroth2Chloe L. Karaskiewicz3Daniel R. Lucas4Elisabeth A. Murray5Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of HealthLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of HealthLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of HealthLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of HealthLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of HealthLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of HealthAbstract Dual-process accounts of item recognition posit two memory processes: slow but detailed recollection, and quick but vague familiarity. It has been proposed, based on prior rodent work, that the amygdala is critical for the familiarity aspect of item recognition. Here, we evaluated this proposal in male rhesus monkeys (Macaca mulatta) with selective bilateral excitotoxic amygdala damage. We used four established visual memory tests designed to assess different aspects of familiarity, all administered on touchscreen computers. Specifically, we assessed monkeys’ tendencies to make low-latency false alarms, to make false alarms to recently seen lures, to produce curvilinear ROC curves, and to discriminate stimuli based on repetition across days. Three of the four tests showed no familiarity impairment and the fourth was explained by a deficit in reward processing. Consistent with this, amygdala damage did produce an anticipated deficit in reward processing in a three-arm-bandit gambling task, verifying the effectiveness of the lesions. Together, these results contradict prior rodent work and suggest that the amygdala is not critical for the familiarity aspect of item recognition.https://doi.org/10.1038/s41467-023-43906-8 |
| spellingShingle | Benjamin M. Basile Vincent D. Costa Jamie L. Schafroth Chloe L. Karaskiewicz Daniel R. Lucas Elisabeth A. Murray The amygdala is not necessary for the familiarity aspect of recognition memory Nature Communications |
| title | The amygdala is not necessary for the familiarity aspect of recognition memory |
| title_full | The amygdala is not necessary for the familiarity aspect of recognition memory |
| title_fullStr | The amygdala is not necessary for the familiarity aspect of recognition memory |
| title_full_unstemmed | The amygdala is not necessary for the familiarity aspect of recognition memory |
| title_short | The amygdala is not necessary for the familiarity aspect of recognition memory |
| title_sort | amygdala is not necessary for the familiarity aspect of recognition memory |
| url | https://doi.org/10.1038/s41467-023-43906-8 |
| work_keys_str_mv | AT benjaminmbasile theamygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT vincentdcosta theamygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT jamielschafroth theamygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT chloelkaraskiewicz theamygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT danielrlucas theamygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT elisabethamurray theamygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT benjaminmbasile amygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT vincentdcosta amygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT jamielschafroth amygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT chloelkaraskiewicz amygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT danielrlucas amygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory AT elisabethamurray amygdalaisnotnecessaryforthefamiliarityaspectofrecognitionmemory |