Surgical Neurostimulation for Spinal Cord Injury
Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3425/7/2/18 |
| _version_ | 1818649394089558016 |
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| author | Aswin Chari Ian D. Hentall Marios C. Papadopoulos Erlick A. C. Pereira |
| author_facet | Aswin Chari Ian D. Hentall Marios C. Papadopoulos Erlick A. C. Pereira |
| author_sort | Aswin Chari |
| collection | DOAJ |
| description | Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI. We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI. |
| first_indexed | 2024-12-17T01:33:37Z |
| format | Article |
| id | doaj.art-7b29fc14b0ab46f79f914e3f9abc7518 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-17T01:33:37Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-7b29fc14b0ab46f79f914e3f9abc75182022-12-21T22:08:30ZengMDPI AGBrain Sciences2076-34252017-02-01721810.3390/brainsci7020018brainsci7020018Surgical Neurostimulation for Spinal Cord InjuryAswin Chari0Ian D. Hentall1Marios C. Papadopoulos2Erlick A. C. Pereira3Academic Neurosurgery Unit, St George’s, University of London, London SW17 0RE, UKThe Miami Project to Cure Paralysis and Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33101, USAAcademic Neurosurgery Unit, St George’s, University of London, London SW17 0RE, UKAcademic Neurosurgery Unit, St George’s, University of London, London SW17 0RE, UKTraumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI. We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.http://www.mdpi.com/2076-3425/7/2/18spinal cord injuryspinal cord stimulationdeep brain stimulationneuromodulation |
| spellingShingle | Aswin Chari Ian D. Hentall Marios C. Papadopoulos Erlick A. C. Pereira Surgical Neurostimulation for Spinal Cord Injury Brain Sciences spinal cord injury spinal cord stimulation deep brain stimulation neuromodulation |
| title | Surgical Neurostimulation for Spinal Cord Injury |
| title_full | Surgical Neurostimulation for Spinal Cord Injury |
| title_fullStr | Surgical Neurostimulation for Spinal Cord Injury |
| title_full_unstemmed | Surgical Neurostimulation for Spinal Cord Injury |
| title_short | Surgical Neurostimulation for Spinal Cord Injury |
| title_sort | surgical neurostimulation for spinal cord injury |
| topic | spinal cord injury spinal cord stimulation deep brain stimulation neuromodulation |
| url | http://www.mdpi.com/2076-3425/7/2/18 |
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