Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Abstract Background According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety behaviors. However, the...

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Bibliographic Details
Main Authors: Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu-Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai, Hsiu Mei Hsieh-Li
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Complementary Medicine and Therapies
Subjects:
PS128 psychobiotic
Streptozotocin
Propionic acid
Gliosis
Glycogen synthase kinase 3 beta
Cognition
Online Access:https://doi.org/10.1186/s12906-021-03426-8

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