Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade
Background: The association between the severity of coronary atherosclerosis and histopathologic findings in patients with non-alcoholic fatty liver disease (NAFLD) is not entirely understood. Considering the gold standard method, this study evaluates the histopathologic association between the seve...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shaheed Beheshti University of Medical Sciences
2024-02-01
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| Series: | International Journal of Medical Toxicology and Forensic Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/ijmtfm/article/view/42742 |
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| author | Behnaz Gholami Manouchehr Khoshbaten Hamidreza Eftekhari Saiedeh Razi Soofiyani Morteza Ghojazadeh Maryam Zaare Nahandi Amir Vahedi Ali Ostadi Ahad Banagozar Mohammadi Artin Kamali Sabeti Ali BanagozarMohammadi Bahram SamadiRad Alireza Najafi Booket |
| author_facet | Behnaz Gholami Manouchehr Khoshbaten Hamidreza Eftekhari Saiedeh Razi Soofiyani Morteza Ghojazadeh Maryam Zaare Nahandi Amir Vahedi Ali Ostadi Ahad Banagozar Mohammadi Artin Kamali Sabeti Ali BanagozarMohammadi Bahram SamadiRad Alireza Najafi Booket |
| author_sort | Behnaz Gholami |
| collection | DOAJ |
| description | Background: The association between the severity of coronary atherosclerosis and histopathologic findings in patients with non-alcoholic fatty liver disease (NAFLD) is not entirely understood. Considering the gold standard method, this study evaluates the histopathologic association between the severity of NAFLD and the grades of coronary atherosclerosis.
Methods: In this descriptive-analytical study, data from 205 cadavers who were referred to an Iranian (Tabriz) forensic medicine organization between 2015 and 2017 and underwent simultaneous liver and coronary artery biopsies were examined. Finally, 168 cases were entered based on the inclusion criteria. First, pathological slides of these cadavers were extracted from the forensic medicine archive and re-examined. Then, the selected cases’ blocks were extracted from the tissue block bank, and again, after preparing a new slide, they were stained with trichrome for accurate estimation of liver fibrosis.
Results: The assessment of NAFLD histological status in the studied cases revealed that 75.6% of the cases were classified as severity I, 18.4% as severity II, and 6% as severity III. Most cases with coronary atherosclerosis were classified as American Heart Association staging (AHA), type V (19.6%), and normal (19.6%). There was no statistically significant relationship between the severity of simple steatosis, steatohepatitis, and NAFLD, with coronary atherosclerosis. In subjects with higher severity of coronary atherosclerosis, the liver fibrosis rate is also higher, but no statistically significant difference was observed.
Conclusion: The present study revealed no significant histopathological association between NAFLD and coronary artery atherosclerosis grade. |
| first_indexed | 2024-03-08T03:28:28Z |
| format | Article |
| id | doaj.art-7b2d4a9b92f842f496759551548e633f |
| institution | Directory Open Access Journal |
| issn | 2251-8762 2251-8770 |
| language | English |
| last_indexed | 2024-03-08T03:28:28Z |
| publishDate | 2024-02-01 |
| publisher | Shaheed Beheshti University of Medical Sciences |
| record_format | Article |
| series | International Journal of Medical Toxicology and Forensic Medicine |
| spelling | doaj.art-7b2d4a9b92f842f496759551548e633f2024-02-11T06:42:27ZengShaheed Beheshti University of Medical SciencesInternational Journal of Medical Toxicology and Forensic Medicine2251-87622251-87702024-02-01141427424274210.32598/ijmtfm.v14i1.4274231304Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis GradeBehnaz Gholami0https://orcid.org/0000-0002-5895-2042Manouchehr Khoshbaten1https://orcid.org/0000-0001-7054-5274Hamidreza Eftekhari2https://orcid.org/0000-0002-8791-6892Saiedeh Razi Soofiyani3https://orcid.org/0000-0002-4623-3024Morteza Ghojazadeh4https://orcid.org/0000-0002-9946-9452Maryam Zaare Nahandi5https://orcid.org/0000-0002-5210-5088Amir Vahedi6Ali Ostadi7https://orcid.org/0000-0001-9868-0080Ahad Banagozar Mohammadi8https://orcid.org/0000-0002-2786-340XArtin Kamali Sabeti9Ali BanagozarMohammadi10https://orcid.org/0000-0002-5255-5804Bahram SamadiRad11https://orcid.org/0000-0002-7770-4298Alireza Najafi Booket12Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Pathology, Legal Medicine Center of East Azerbaijan, Tabriz, Iran.Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.Evidence-Based Medicine Research Center, Iranian EBM Center, Tabriz University of Medical Sciences, Tabriz, Iran.Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Forensic Medicine, Legal Medicine Research Center, Legal Medicine Center of East Azerbaijan, Tabriz, Iran. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Forensic Medicine, Legal Medicine Research Center, Legal Medicine Center of East Azerbaijan, Tabriz, Iran. Department of Pathology, Legal Medicine Center of East Azerbaijan, Tabriz, Iran.Background: The association between the severity of coronary atherosclerosis and histopathologic findings in patients with non-alcoholic fatty liver disease (NAFLD) is not entirely understood. Considering the gold standard method, this study evaluates the histopathologic association between the severity of NAFLD and the grades of coronary atherosclerosis. Methods: In this descriptive-analytical study, data from 205 cadavers who were referred to an Iranian (Tabriz) forensic medicine organization between 2015 and 2017 and underwent simultaneous liver and coronary artery biopsies were examined. Finally, 168 cases were entered based on the inclusion criteria. First, pathological slides of these cadavers were extracted from the forensic medicine archive and re-examined. Then, the selected cases’ blocks were extracted from the tissue block bank, and again, after preparing a new slide, they were stained with trichrome for accurate estimation of liver fibrosis. Results: The assessment of NAFLD histological status in the studied cases revealed that 75.6% of the cases were classified as severity I, 18.4% as severity II, and 6% as severity III. Most cases with coronary atherosclerosis were classified as American Heart Association staging (AHA), type V (19.6%), and normal (19.6%). There was no statistically significant relationship between the severity of simple steatosis, steatohepatitis, and NAFLD, with coronary atherosclerosis. In subjects with higher severity of coronary atherosclerosis, the liver fibrosis rate is also higher, but no statistically significant difference was observed. Conclusion: The present study revealed no significant histopathological association between NAFLD and coronary artery atherosclerosis grade.https://journals.sbmu.ac.ir/ijmtfm/article/view/42742non-alcoholic fatty liver diseasenafldcoronary atherosclerosishistologycardiovascular diseases |
| spellingShingle | Behnaz Gholami Manouchehr Khoshbaten Hamidreza Eftekhari Saiedeh Razi Soofiyani Morteza Ghojazadeh Maryam Zaare Nahandi Amir Vahedi Ali Ostadi Ahad Banagozar Mohammadi Artin Kamali Sabeti Ali BanagozarMohammadi Bahram SamadiRad Alireza Najafi Booket Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade International Journal of Medical Toxicology and Forensic Medicine non-alcoholic fatty liver disease nafld coronary atherosclerosis histology cardiovascular diseases |
| title | Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade |
| title_full | Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade |
| title_fullStr | Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade |
| title_full_unstemmed | Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade |
| title_short | Histopathological Association of Non-alcoholic Fatty Liver Disease With Coronary Artery Atherosclerosis Grade |
| title_sort | histopathological association of non alcoholic fatty liver disease with coronary artery atherosclerosis grade |
| topic | non-alcoholic fatty liver disease nafld coronary atherosclerosis histology cardiovascular diseases |
| url | https://journals.sbmu.ac.ir/ijmtfm/article/view/42742 |
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