Features of nutritional support during stem cell transplantation
This article presented a review of the literature on the features of nutritional support for oncohematological patients who have undergone allogeneic (alloHSCT)/autologous hematopoietic stem cell transplantation (autoHSCT). Bone marrow transplantation associated with a high risk of developing nutrit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2020-07-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/5719 |
| _version_ | 1797842178164129792 |
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| author | S. A. Volchenkov L. V. Filatova E. V. Cherkasova A. K. Koviazin S. V. Lyubimov I. S. Zyuzgin T. Yu. Semiglazova |
| author_facet | S. A. Volchenkov L. V. Filatova E. V. Cherkasova A. K. Koviazin S. V. Lyubimov I. S. Zyuzgin T. Yu. Semiglazova |
| author_sort | S. A. Volchenkov |
| collection | DOAJ |
| description | This article presented a review of the literature on the features of nutritional support for oncohematological patients who have undergone allogeneic (alloHSCT)/autologous hematopoietic stem cell transplantation (autoHSCT). Bone marrow transplantation associated with a high risk of developing nutritional deficiencies. Nutritional support (NP) is indicated for patients undergoing alloHSCT and autoHSCT in order to reduce the incidence of infectious complications and reduce the risk of developing severe forms of acute and chronic GVHD. Currently, there are recommendations for conducting NP in alloHSCT, while there are no recommendations for patients with autoHSCT. An important task in planning NP is the calculation of the daily energy requirement. Bone marrow transplantation accompanied by a prolonged negative nitrogen balance. The protein requirement for alloHSCT is significantly higher than for patients with chemotherapy alone – 1.5–2 g/kg per day. An effective method of controlling the needs of hematological patients during the analysis of HSCT and alloHSCT is the calculation of the nitrogen balance and the daily protein norm. In this article was analyzed the role of macronutrients and immunonutrients in the recovery of patients during alloHSCT. It has been shown that low levels of vitamin D and vitamin A increase the risk of development and the severity of the transplant versus host reaction. The addition of omega-3 fatty acids helps maintain an optimal proportion of calorie intake from lipids, as well as maintain the necessary level of triglycerides in the blood. The article presents data on reducing the risk of developing acute GVHD with systemic addition of omega-3 fatty acids. For a final assessment of the effect of the neutropenic diet on the development of infectious complications in oncohematological patients, randomized prospective multicenter studies with the development of a unified approach in choosing a diet for HSCT are needed. |
| first_indexed | 2024-04-09T16:43:36Z |
| format | Article |
| id | doaj.art-7b2dc6006bd34d2084a36a890ff2afa7 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:43:36Z |
| publishDate | 2020-07-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-7b2dc6006bd34d2084a36a890ff2afa72023-04-23T06:56:34ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902020-07-010915616410.21518/2079-701X-2020-9-156-1645199Features of nutritional support during stem cell transplantationS. A. Volchenkov0L. V. Filatova1E. V. Cherkasova2A. K. Koviazin3S. V. Lyubimov4I. S. Zyuzgin5T. Yu. Semiglazova6Petrov National Medical Cancer Research CentrePetrov National Medical Cancer Research Centre; North-Western State Medical University named after I.I. MechnikovPetrov National Medical Cancer Research CentrePetrov National Medical Cancer Research CentrePetrov National Medical Cancer Research CentrePetrov National Medical Cancer Research CentrePetrov National Medical Cancer Research Centre; North-Western State Medical University named after I.I. MechnikovThis article presented a review of the literature on the features of nutritional support for oncohematological patients who have undergone allogeneic (alloHSCT)/autologous hematopoietic stem cell transplantation (autoHSCT). Bone marrow transplantation associated with a high risk of developing nutritional deficiencies. Nutritional support (NP) is indicated for patients undergoing alloHSCT and autoHSCT in order to reduce the incidence of infectious complications and reduce the risk of developing severe forms of acute and chronic GVHD. Currently, there are recommendations for conducting NP in alloHSCT, while there are no recommendations for patients with autoHSCT. An important task in planning NP is the calculation of the daily energy requirement. Bone marrow transplantation accompanied by a prolonged negative nitrogen balance. The protein requirement for alloHSCT is significantly higher than for patients with chemotherapy alone – 1.5–2 g/kg per day. An effective method of controlling the needs of hematological patients during the analysis of HSCT and alloHSCT is the calculation of the nitrogen balance and the daily protein norm. In this article was analyzed the role of macronutrients and immunonutrients in the recovery of patients during alloHSCT. It has been shown that low levels of vitamin D and vitamin A increase the risk of development and the severity of the transplant versus host reaction. The addition of omega-3 fatty acids helps maintain an optimal proportion of calorie intake from lipids, as well as maintain the necessary level of triglycerides in the blood. The article presents data on reducing the risk of developing acute GVHD with systemic addition of omega-3 fatty acids. For a final assessment of the effect of the neutropenic diet on the development of infectious complications in oncohematological patients, randomized prospective multicenter studies with the development of a unified approach in choosing a diet for HSCT are needed.https://www.med-sovet.pro/jour/article/view/5719nutritional supportnutritional insufficiencyallogeneic and autologous hematopoietic stem cell transplantationimmunonutrientsneutropenic diet |
| spellingShingle | S. A. Volchenkov L. V. Filatova E. V. Cherkasova A. K. Koviazin S. V. Lyubimov I. S. Zyuzgin T. Yu. Semiglazova Features of nutritional support during stem cell transplantation Медицинский совет nutritional support nutritional insufficiency allogeneic and autologous hematopoietic stem cell transplantation immunonutrients neutropenic diet |
| title | Features of nutritional support during stem cell transplantation |
| title_full | Features of nutritional support during stem cell transplantation |
| title_fullStr | Features of nutritional support during stem cell transplantation |
| title_full_unstemmed | Features of nutritional support during stem cell transplantation |
| title_short | Features of nutritional support during stem cell transplantation |
| title_sort | features of nutritional support during stem cell transplantation |
| topic | nutritional support nutritional insufficiency allogeneic and autologous hematopoietic stem cell transplantation immunonutrients neutropenic diet |
| url | https://www.med-sovet.pro/jour/article/view/5719 |
| work_keys_str_mv | AT savolchenkov featuresofnutritionalsupportduringstemcelltransplantation AT lvfilatova featuresofnutritionalsupportduringstemcelltransplantation AT evcherkasova featuresofnutritionalsupportduringstemcelltransplantation AT akkoviazin featuresofnutritionalsupportduringstemcelltransplantation AT svlyubimov featuresofnutritionalsupportduringstemcelltransplantation AT iszyuzgin featuresofnutritionalsupportduringstemcelltransplantation AT tyusemiglazova featuresofnutritionalsupportduringstemcelltransplantation |