Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study
Purpose: Primary hepatic sarcomatoid carcinoma (PHSC) is a rare type of malignant tumor in the liver. Nevertheless, few studies have focused on the imaging diagnosis of PHSC. In this study, we collected clinical and computed tomography (CT) imaging data of PHSC from two institutions, aiming to inves...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023013300 |
| _version_ | 1797851857343741952 |
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| author | Lintao Chen Shijian Ruan Pan Wang Yongna Cheng Yubizhuo Wang Wuwei Tian Hongbin Zhang Xiuming Zhang Wenjie Liang |
| author_facet | Lintao Chen Shijian Ruan Pan Wang Yongna Cheng Yubizhuo Wang Wuwei Tian Hongbin Zhang Xiuming Zhang Wenjie Liang |
| author_sort | Lintao Chen |
| collection | DOAJ |
| description | Purpose: Primary hepatic sarcomatoid carcinoma (PHSC) is a rare type of malignant tumor in the liver. Nevertheless, few studies have focused on the imaging diagnosis of PHSC. In this study, we collected clinical and computed tomography (CT) imaging data of PHSC from two institutions, aiming to investigate the clinical and radiological characteristics of PHSC. Methods: We retrospectively investigated the clinical characteristics and CT features of 22 PHSC patients (19 males and 3 females; mean age, 63.4 years; range, 49 to 76 years), 95 hepatocellular carcinoma (HCC) patients and 50 intrahepatic cholangiocarcinoma (ICC) patients. Two radiologists independently evaluated the CT features of the three groups. Subsequently, we analyzed the differences in the clinical characteristics and CT features between the PHSC and control groups. Results: Most PHSCs were larger than 5 cm (72.7%). PHSC mainly showed irregular (81.8%), heterogeneous (100%) masses with ill-defined (72.7%) borders with necrosis (86.4%) on CT, which are more common CT features versus HCC (p < 0.001). In the arterial phase, PHSC always showed noticeable heterogeneous enhancement (100.0%), mainly manifesting as partial arterial phase hyperenhancement (APHE) (86.4%). The enhancement patterns of PHSC mainly included delayed progressive enhancement (72.7%), nonperipheral washout (22.7%), and unclassified enhancement (4.5%), which were significantly different from the HCC enhancement pattern but similar to the enhancement pattern of ICC. In addition, vein tumor thrombus (18.2%), intrahepatic metastasis (27.3%), and lymphadenopathy (27.3%) were relatively common in PHSC. Furthermore, most PHSC tumors classified as LR-M (66.7%) were similar to ICC. Conclusions: PHSC generally presents as irregularly large masses with necrosis, intrahepatic metastasis, and lymphadenopathy. The CT enhancement of PHSC is mainly part of APHE and delayed progressive enhancement. |
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| id | doaj.art-7b2e6e64270d4700a10ee1df683bccc5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:24:34Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj.art-7b2e6e64270d4700a10ee1df683bccc52023-04-05T08:20:53ZengElsevierHeliyon2405-84402023-03-0193e14123Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary studyLintao Chen0Shijian Ruan1Pan Wang2Yongna Cheng3Yubizhuo Wang4Wuwei Tian5Hongbin Zhang6Xiuming Zhang7Wenjie Liang8Department of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, China; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Information Science & Electronic Engineering, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, ChinaDepartment of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, China; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaCollege of Information Science & Electronic Engineering, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Corresponding author. 79# Qingchun Road, Hangzhou, Zhejiang Province, China.Purpose: Primary hepatic sarcomatoid carcinoma (PHSC) is a rare type of malignant tumor in the liver. Nevertheless, few studies have focused on the imaging diagnosis of PHSC. In this study, we collected clinical and computed tomography (CT) imaging data of PHSC from two institutions, aiming to investigate the clinical and radiological characteristics of PHSC. Methods: We retrospectively investigated the clinical characteristics and CT features of 22 PHSC patients (19 males and 3 females; mean age, 63.4 years; range, 49 to 76 years), 95 hepatocellular carcinoma (HCC) patients and 50 intrahepatic cholangiocarcinoma (ICC) patients. Two radiologists independently evaluated the CT features of the three groups. Subsequently, we analyzed the differences in the clinical characteristics and CT features between the PHSC and control groups. Results: Most PHSCs were larger than 5 cm (72.7%). PHSC mainly showed irregular (81.8%), heterogeneous (100%) masses with ill-defined (72.7%) borders with necrosis (86.4%) on CT, which are more common CT features versus HCC (p < 0.001). In the arterial phase, PHSC always showed noticeable heterogeneous enhancement (100.0%), mainly manifesting as partial arterial phase hyperenhancement (APHE) (86.4%). The enhancement patterns of PHSC mainly included delayed progressive enhancement (72.7%), nonperipheral washout (22.7%), and unclassified enhancement (4.5%), which were significantly different from the HCC enhancement pattern but similar to the enhancement pattern of ICC. In addition, vein tumor thrombus (18.2%), intrahepatic metastasis (27.3%), and lymphadenopathy (27.3%) were relatively common in PHSC. Furthermore, most PHSC tumors classified as LR-M (66.7%) were similar to ICC. Conclusions: PHSC generally presents as irregularly large masses with necrosis, intrahepatic metastasis, and lymphadenopathy. The CT enhancement of PHSC is mainly part of APHE and delayed progressive enhancement.http://www.sciencedirect.com/science/article/pii/S2405844023013300Hepatic sarcomatoid carcinomaImagingComputed tomographyHepatocellular carcinomaIntrahepatic cholangiocarcinoma |
| spellingShingle | Lintao Chen Shijian Ruan Pan Wang Yongna Cheng Yubizhuo Wang Wuwei Tian Hongbin Zhang Xiuming Zhang Wenjie Liang Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study Heliyon Hepatic sarcomatoid carcinoma Imaging Computed tomography Hepatocellular carcinoma Intrahepatic cholangiocarcinoma |
| title | Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study |
| title_full | Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study |
| title_fullStr | Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study |
| title_full_unstemmed | Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study |
| title_short | Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study |
| title_sort | imaging features of primary hepatic sarcomatoid carcinoma differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on ct a preliminary study |
| topic | Hepatic sarcomatoid carcinoma Imaging Computed tomography Hepatocellular carcinoma Intrahepatic cholangiocarcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023013300 |
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