Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration

Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration

Age-related macular degeneration (AMD) is a major cause of irreversible blindness among the elderly population. Dysfunction and degeneration of the retinal pigment epithelial (RPE) layer in the retina underscore the pathogenesis of both dry and wet AMD. Advanced age, cigarette smoke and genetic fact...

Full description

Bibliographic Details
Main Authors:	Yao Tong, Shusheng Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	AMD RPE oxidative stress senescence cell death
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2020.591067/full

Similar Items

Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration
by: Yao Tong, et al.
Published: (2022-07-01)

Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H Variant
by: Henry Velazquez-Soto, et al.
Published: (2023-07-01)

Acute mechanical stress in primary porcine RPE cells induces angiogenic factor expression and in vitro angiogenesis
by: Farhad Farjood, et al.
Published: (2020-04-01)

Comparative mechanistic study of RPE cell death induced by different oxidative stresses
by: Yao Tong, et al.
Published: (2023-09-01)

The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress
by: Xiaojun Wu, et al.
Published: (2022-09-01)

Bevacizumab cured age-related macular degeneration (AMD) via down-regulate TLR2 pathway
by: Wang Zhi, et al.
Published: (2014-05-01)

Relative Contribution of Different Mitochondrial Oxidative Phosphorylation Components to the Retinal Pigment Epithelium Barrier Function: Implications for RPE-Related Retinal Diseases
by: Michael H. Guerra, et al.
Published: (2021-07-01)

DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features
by: Xiaoyin Ma, et al.
Published: (2023-06-01)

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
by: Eloise Keeling, et al.
Published: (2018-02-01)

A model to study complement involvement in experimental retinal degeneration
by: Camilla Mohlin, et al.
Published: (2018-01-01)

Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology
by: Shuo Sun, et al.
Published: (2017-06-01)

Suspension of Anti-VEGF Treatment Does Not Affect Expansion of RPE Atrophy in Neovascular Age-Related Macular Degeneration
by: Shinichiro Chujo, et al.
Published: (2023-05-01)

PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE
by: Ivan T. Rebustini, et al.
Published: (2022-07-01)

Analysis of the injuries and workload evolution using the RPE and s-RPE method in basketball
by: Laura Garcia, et al.
Published: (2022-01-01)

Crocetin Prevents RPE Cells from Oxidative Stress through Protection of Cellular Metabolic Function and Activation of ERK1/2
by: Padideh Karimi, et al.
Published: (2020-04-01)

Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
by: Angela Armento, et al.
Published: (2021-11-01)

Antioxidant Properties of Cerium Oxide Nanoparticles Prevent Retinal Neovascular Alterations In Vitro and In Vivo
by: Annamaria Tisi, et al.
Published: (2022-06-01)

Cellular models and therapies for age-related macular degeneration
by: David L. Forest, et al.
Published: (2015-05-01)

Proteins Associated with Phagocytosis Alteration in Retinal Pigment Epithelial Cells Derived from Age-Related Macular Degeneration Patients
by: Audrey Voisin, et al.
Published: (2022-04-01)

Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina
by: Sudha Ananth, et al.
Published: (2020-12-01)

Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis
by: Agnes Fietz, et al.
Published: (2023-12-01)

Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence
by: Wanting Shu, et al.
Published: (2020-07-01)

AMD-Like Substrate Causes Epithelial Mesenchymal Transition in iPSC-Derived Retinal Pigment Epithelial Cells Wild Type but Not <i>C3</i>-Knockout
by: Blanca Chinchilla, et al.
Published: (2021-07-01)

Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degeneration
by: Dhanach Dhirachaikulpanich, et al.
Published: (2022-11-01)

Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium
by: Michele Catanzaro, et al.
Published: (2020-06-01)

Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration
by: Treefa Shwani, et al.
Published: (2023-11-01)

The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
by: Zuhal Yildirim, et al.
Published: (2011-01-01)

An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy
by: Eloise Keeling, et al.
Published: (2020-09-01)

cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium
by: Jing Li, et al.
Published: (2022-07-01)

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway
by: Angela Armento, et al.
Published: (2021-08-01)

Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
by: Meng Zhang, et al.
Published: (2018-09-01)

Polarized desmosome and hemidesmosome shedding via small extracellular vesicles is an early indicator of outer blood‐retina barrier dysfunction
by: Belinda J. Hernandez, et al.
Published: (2023-10-01)

PEDF Prevents Mitochondrial Function Decay and ER Stress Induced by Rotenone in Aging RPE Cells
by: Ruixue Zhang, et al.
Published: (2023-11-01)

Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR
by: Haiting Chen, et al.
Published: (2018-03-01)

Exosomal MiRNA Transfer between Retinal Microglia and RPE
by: Dorothea R. Morris, et al.
Published: (2020-05-01)

Beyond RPE: The Perception of Exercise Under Normal and Ketotic Conditions
by: Olivia K. Faull, et al.
Published: (2019-03-01)

The Effect of Polyhydroxyethylmethacrylate (Poly-HEMA), as a Cell Culture Substrate, on Viable and Preserving Nature of Retinal Pigment Epithelium (RPE) Cells
by: Fatemeh Nazem-Roaya, et al.
Published: (2014-11-01)

EFFICIENCY OF AFLIBERCEPT IN CLINICAL PRACTICE
by: A. V. Kulagina
Published: (2017-09-01)

Editorial: Fruit Responses to Biotic and Abiotic Stressors During Postharvest
by: Isabel Lara, et al.
Published: (2022-04-01)

CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage
by: Ye Liu, et al.
Published: (2023-01-01)