STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION
This study evaluates the compatibility and stability of Taxol with ondansetron, ranitidine, vancomycin and cephalosporins in 5% dextrose injection and 0.9% sodium chloride injection during simulated Y-site administration. Two stock solutions of Taxol 0.3 and 1.2 mg/mL and each stock solutions of ond...
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| Format: | Article |
| Language: | English |
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Universiti Sains Malaysia
2005-01-01
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| Series: | Malaysian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.usm.my/mjps/MJPS%203(2)%202005/MJPS%203.2.4.pdf |
| _version_ | 1811238790409224192 |
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| author | JIN PIL BURM |
| author_facet | JIN PIL BURM |
| author_sort | JIN PIL BURM |
| collection | DOAJ |
| description | This study evaluates the compatibility and stability of Taxol with ondansetron, ranitidine, vancomycin and cephalosporins in 5% dextrose injection and 0.9% sodium chloride injection during simulated Y-site administration. Two stock solutions of Taxol 0.3 and 1.2 mg/mL and each stock solutions of ondansetron 0.03, 0.1 and 0.3 mg/mL, ranitidine 0.5 and 2 mg/mL, vancomycin 1, 5 and 10 mg/mL and cephalosporins 20 mg/mL were prepared in glass bottles. Two mL of Taxol stock solution was mixed with 2 mL of each stock solution. Samples were removed at room temperature at time zero, one, two, four and 12 hours for immediate assay. Taxol concentrations were analyzed by High Performance Liquid Chromatography. All solutions were prepared in triplicate, and each drug was assayed in duplicate. At the time of sampling assay and before any dilution, each sample was visually inspected for clarity, color and precipitation. The pH was also determined. Taxol in concentrations of 0.3 and 1.2 mg/mL was stable when mixed with either ondansetron (0.03, 0.1 or 0.3 mg/mL, as the hydrochloride salt), ranitidine (0.5 or 2.0 mg/mL, as the hydrochloride salt), vancomycin (1, 5 or 10 mg/mL, as the hydrochloride salt) or cephalosporins 20 mg/mL and stored in glass containers for 12 hours. No precipitates, color changes, or haziness was seen. The changes in pH were minor. |
| first_indexed | 2024-04-12T12:47:18Z |
| format | Article |
| id | doaj.art-7b320bfd0c5f4ad4bedd574e1c942752 |
| institution | Directory Open Access Journal |
| issn | 1675-7319 1985-8396 |
| language | English |
| last_indexed | 2024-04-12T12:47:18Z |
| publishDate | 2005-01-01 |
| publisher | Universiti Sains Malaysia |
| record_format | Article |
| series | Malaysian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-7b320bfd0c5f4ad4bedd574e1c9427522022-12-22T03:32:34ZengUniversiti Sains MalaysiaMalaysian Journal of Pharmaceutical Sciences1675-73191985-83962005-01-01323141STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATIONJIN PIL BURMThis study evaluates the compatibility and stability of Taxol with ondansetron, ranitidine, vancomycin and cephalosporins in 5% dextrose injection and 0.9% sodium chloride injection during simulated Y-site administration. Two stock solutions of Taxol 0.3 and 1.2 mg/mL and each stock solutions of ondansetron 0.03, 0.1 and 0.3 mg/mL, ranitidine 0.5 and 2 mg/mL, vancomycin 1, 5 and 10 mg/mL and cephalosporins 20 mg/mL were prepared in glass bottles. Two mL of Taxol stock solution was mixed with 2 mL of each stock solution. Samples were removed at room temperature at time zero, one, two, four and 12 hours for immediate assay. Taxol concentrations were analyzed by High Performance Liquid Chromatography. All solutions were prepared in triplicate, and each drug was assayed in duplicate. At the time of sampling assay and before any dilution, each sample was visually inspected for clarity, color and precipitation. The pH was also determined. Taxol in concentrations of 0.3 and 1.2 mg/mL was stable when mixed with either ondansetron (0.03, 0.1 or 0.3 mg/mL, as the hydrochloride salt), ranitidine (0.5 or 2.0 mg/mL, as the hydrochloride salt), vancomycin (1, 5 or 10 mg/mL, as the hydrochloride salt) or cephalosporins 20 mg/mL and stored in glass containers for 12 hours. No precipitates, color changes, or haziness was seen. The changes in pH were minor.http://www.usm.my/mjps/MJPS%203(2)%202005/MJPS%203.2.4.pdfStabilityTaxolOndansetronRanitidineVancomycinCephalosporins |
| spellingShingle | JIN PIL BURM STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION Malaysian Journal of Pharmaceutical Sciences Stability Taxol Ondansetron Ranitidine Vancomycin Cephalosporins |
| title | STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION |
| title_full | STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION |
| title_fullStr | STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION |
| title_full_unstemmed | STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION |
| title_short | STABILITY AND COMPATIBILITY OF TAXOL WITH VARIOUS DRUGS DURING SIMULATED Y-SITE ADMINISTRATION |
| title_sort | stability and compatibility of taxol with various drugs during simulated y site administration |
| topic | Stability Taxol Ondansetron Ranitidine Vancomycin Cephalosporins |
| url | http://www.usm.my/mjps/MJPS%203(2)%202005/MJPS%203.2.4.pdf |
| work_keys_str_mv | AT jinpilburm stabilityandcompatibilityoftaxolwithvariousdrugsduringsimulatedysiteadministration |