Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1β Dependent Manner

Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1β Dependent Manner

Neutrophils are key first-responders in the innate immune response to C. difficile infection (CDI) and play a central role in disease pathogenesis. Studies have clearly shown that tissue neutrophil numbers need to be tightly regulated for optimal CDI outcomes: while excessive colonic neutrophilia is...

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Bibliographic Details
Main Authors: Olivia Horrigan, Shinsmon Jose, Anindita Mukherjee, Divya Sharma, Alexander Huber, Rajat Madan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
LEPR Q223R gene polymorphism
Clostridioides (C.) difficile
CXCR2
IL-1β
neutrophilia
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.619192/full

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