An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma
Waldenström macroglobulinemia/lymphoplasmacytoid lymphoma (WM/LPL) is a rare lymphoproliferative neoplasm characterized by clonally related lymphocytes, lymphoplasmacytic cells, and plasma cell proliferation. WM/LPL patients commonly present with elevated immunoglobulin, predominantly immunoglobulin...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.870258/full |
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| author | Xinting Hu Xinting Hu Xinting Hu Xinting Hu Hua Wang Hua Wang Dai Yuan Dai Yuan Dai Yuan Dai Yuan Dai Yuan Dai Yuan Huiting Qu Huiting Qu Huiting Qu Huiting Qu Huiting Qu Huiting Qu Ying Li Ying Li Ying Li Ying Li Ying Li Ying Li Na Wang Na Wang Na Wang Na Wang Na Wang Na Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xin Liu Xin Liu Xin Liu Xin Liu Xin Liu Xin Liu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Ya Zhang Ya Zhang Ya Zhang Ya Zhang Xin Wang Xin Wang Xin Wang Xin Wang Xin Wang Xin Wang |
| author_facet | Xinting Hu Xinting Hu Xinting Hu Xinting Hu Hua Wang Hua Wang Dai Yuan Dai Yuan Dai Yuan Dai Yuan Dai Yuan Dai Yuan Huiting Qu Huiting Qu Huiting Qu Huiting Qu Huiting Qu Huiting Qu Ying Li Ying Li Ying Li Ying Li Ying Li Ying Li Na Wang Na Wang Na Wang Na Wang Na Wang Na Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xin Liu Xin Liu Xin Liu Xin Liu Xin Liu Xin Liu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Ya Zhang Ya Zhang Ya Zhang Ya Zhang Xin Wang Xin Wang Xin Wang Xin Wang Xin Wang Xin Wang |
| author_sort | Xinting Hu |
| collection | DOAJ |
| description | Waldenström macroglobulinemia/lymphoplasmacytoid lymphoma (WM/LPL) is a rare lymphoproliferative neoplasm characterized by clonally related lymphocytes, lymphoplasmacytic cells, and plasma cell proliferation. WM/LPL patients commonly present with elevated immunoglobulin, predominantly immunoglobulin M (IgM). Previous studies reported that thyroid dysfunction was associated with the development and progression of solid tumors. However, only limited information is available on the correlation between thyroid complications and lymphoid malignancies. The aim of our study was to explore the prognostic significance of thyroid complications in WM/LPL. Herein, 13.3% of WM/LPL patients were diagnosed with thyroid complications, which were significantly associated with unfavorable progression-free survival (PFS), overall survival (OS), and adverse treatment response. Co-existing thyroid disease was significantly related to alleviated serum IgM levels, providing an answer to practical problems. Furthermore, the presence of thyroid complications was identified as an independent prognostic indicator for PFS in WM/LPL. Incorporating the ISSWM score with thyroid complications was superior to ISSWM alone in risk stratification and prognostic prediction. Furthermore, subgroup analyses of WM/LPL patients revealed that subclinical hypothyroidism predicted undesirable outcomes at the early stage. These results were also supported by independent microarray dataset analyses. In conclusion, the primary strength of this study is that it provides robust real-world evidence on the prognostic role of thyroid complications, highlighting further clinical concerns in the management of WM/LPL patients. |
| first_indexed | 2024-04-12T17:21:47Z |
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| id | doaj.art-7b33b955b4f14712be2d8d519924f9cb |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T17:21:47Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-7b33b955b4f14712be2d8d519924f9cb2022-12-22T03:23:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.870258870258An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid LymphomaXinting Hu0Xinting Hu1Xinting Hu2Xinting Hu3Hua Wang4Hua Wang5Dai Yuan6Dai Yuan7Dai Yuan8Dai Yuan9Dai Yuan10Dai Yuan11Huiting Qu12Huiting Qu13Huiting Qu14Huiting Qu15Huiting Qu16Huiting Qu17Ying Li18Ying Li19Ying Li20Ying Li21Ying Li22Ying Li23Na Wang24Na Wang25Na Wang26Na Wang27Na Wang28Na Wang29Xianghua Wang30Xianghua Wang31Xianghua Wang32Xianghua Wang33Xianghua Wang34Xianghua Wang35Xin Liu36Xin Liu37Xin Liu38Xin Liu39Xin Liu40Xin Liu41Hongzhi Xu42Hongzhi Xu43Hongzhi Xu44Hongzhi Xu45Hongzhi Xu46Hongzhi Xu47Ya Zhang48Ya Zhang49Ya Zhang50Ya Zhang51Xin Wang52Xin Wang53Xin Wang54Xin Wang55Xin Wang56Xin Wang57Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaShandong Provincial Engineering Research Center of Lymphoma, Jinan, ChinaBranch of National Clinical Research Center for Hematologic Diseases, Jinan, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaWaldenström macroglobulinemia/lymphoplasmacytoid lymphoma (WM/LPL) is a rare lymphoproliferative neoplasm characterized by clonally related lymphocytes, lymphoplasmacytic cells, and plasma cell proliferation. WM/LPL patients commonly present with elevated immunoglobulin, predominantly immunoglobulin M (IgM). Previous studies reported that thyroid dysfunction was associated with the development and progression of solid tumors. However, only limited information is available on the correlation between thyroid complications and lymphoid malignancies. The aim of our study was to explore the prognostic significance of thyroid complications in WM/LPL. Herein, 13.3% of WM/LPL patients were diagnosed with thyroid complications, which were significantly associated with unfavorable progression-free survival (PFS), overall survival (OS), and adverse treatment response. Co-existing thyroid disease was significantly related to alleviated serum IgM levels, providing an answer to practical problems. Furthermore, the presence of thyroid complications was identified as an independent prognostic indicator for PFS in WM/LPL. Incorporating the ISSWM score with thyroid complications was superior to ISSWM alone in risk stratification and prognostic prediction. Furthermore, subgroup analyses of WM/LPL patients revealed that subclinical hypothyroidism predicted undesirable outcomes at the early stage. These results were also supported by independent microarray dataset analyses. In conclusion, the primary strength of this study is that it provides robust real-world evidence on the prognostic role of thyroid complications, highlighting further clinical concerns in the management of WM/LPL patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.870258/fullWaldenström macroglobulinemia/lymphoplasmacytoid lymphomathyroid complicationssurvivalimmunoglobulin Mretrospective |
| spellingShingle | Xinting Hu Xinting Hu Xinting Hu Xinting Hu Hua Wang Hua Wang Dai Yuan Dai Yuan Dai Yuan Dai Yuan Dai Yuan Dai Yuan Huiting Qu Huiting Qu Huiting Qu Huiting Qu Huiting Qu Huiting Qu Ying Li Ying Li Ying Li Ying Li Ying Li Ying Li Na Wang Na Wang Na Wang Na Wang Na Wang Na Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xianghua Wang Xin Liu Xin Liu Xin Liu Xin Liu Xin Liu Xin Liu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Hongzhi Xu Ya Zhang Ya Zhang Ya Zhang Ya Zhang Xin Wang Xin Wang Xin Wang Xin Wang Xin Wang Xin Wang An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma Frontiers in Oncology Waldenström macroglobulinemia/lymphoplasmacytoid lymphoma thyroid complications survival immunoglobulin M retrospective |
| title | An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma |
| title_full | An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma |
| title_fullStr | An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma |
| title_full_unstemmed | An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma |
| title_short | An Extended Prognostic Index of the ISSWM Score Based on Thyroid Complications in Waldenström Macroglobulinemia/Lymphoplasmacytoid Lymphoma |
| title_sort | extended prognostic index of the isswm score based on thyroid complications in waldenstrom macroglobulinemia lymphoplasmacytoid lymphoma |
| topic | Waldenström macroglobulinemia/lymphoplasmacytoid lymphoma thyroid complications survival immunoglobulin M retrospective |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.870258/full |
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