Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations
Abstract Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found on natural killer cells and some T-lymphocytes are genetically diverse and play key...
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Format: | Article |
Language: | English |
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BMC
2023-03-01
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Series: | Translational Medicine Communications |
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Online Access: | https://doi.org/10.1186/s41231-023-00141-z |
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author | John Mukisa Marion Amujal Obondo J. Sande Moses L. Joloba Daudi Jjingo David P. Kateete Graeme Mardon Mogomotsi Matshaba Neil Hanchard Jill A. Hollenbach |
author_facet | John Mukisa Marion Amujal Obondo J. Sande Moses L. Joloba Daudi Jjingo David P. Kateete Graeme Mardon Mogomotsi Matshaba Neil Hanchard Jill A. Hollenbach |
author_sort | John Mukisa |
collection | DOAJ |
description | Abstract Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found on natural killer cells and some T-lymphocytes are genetically diverse and play key functions in the host response against viral pathogens. In the last decade, there has been substantial growth in sequencing technologies and bioinformatics capacity to understand human host genetics, including KIR. However, there is limited literature on how the KIR diversity informs the perspectives on HIV disease states in understudied African settings. A better understanding of the effects of KIRs on the host’s immune response to HIV in African settings is essential to inform strategies to develop more effective therapies and vaccines to improve health among people living with HIV (PLWH). In this paper, we review KIR diversity, the role of KIR immunogenetic variation in the human host response to HIV, discuss current perspectives on the studies to assess the relationship between KIR diversity and the HIV disease continuum, and suggest future research prospects. |
first_indexed | 2024-04-09T22:45:58Z |
format | Article |
id | doaj.art-7b34a82e753f41b8be9e240f53200078 |
institution | Directory Open Access Journal |
issn | 2396-832X |
language | English |
last_indexed | 2024-04-09T22:45:58Z |
publishDate | 2023-03-01 |
publisher | BMC |
record_format | Article |
series | Translational Medicine Communications |
spelling | doaj.art-7b34a82e753f41b8be9e240f532000782023-03-22T11:50:35ZengBMCTranslational Medicine Communications2396-832X2023-03-01811910.1186/s41231-023-00141-zKiller cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populationsJohn Mukisa0Marion Amujal1Obondo J. Sande2Moses L. Joloba3Daudi Jjingo4David P. Kateete5Graeme Mardon6Mogomotsi Matshaba7Neil Hanchard8Jill A. Hollenbach9Department of Immunology and Molecular Biology, College of Health Sciences, Makerere UniversityDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere UniversityDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere UniversityDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere UniversityCollege of Computing and Information Sciences, Makerere UniversityDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere UniversityDepartment of Molecular and Human Genetics and Department of Pathology and Immunology, Baylor College of MedicineBotswana-Baylor Children’s Clinical Centre of ExcellenceDepartment of Molecular and Human Genetics and Department of Pathology and Immunology, Baylor College of MedicineDepartment of Neurology and Department of Epidemiology and Biostatistics, University of California San FranciscoAbstract Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found on natural killer cells and some T-lymphocytes are genetically diverse and play key functions in the host response against viral pathogens. In the last decade, there has been substantial growth in sequencing technologies and bioinformatics capacity to understand human host genetics, including KIR. However, there is limited literature on how the KIR diversity informs the perspectives on HIV disease states in understudied African settings. A better understanding of the effects of KIRs on the host’s immune response to HIV in African settings is essential to inform strategies to develop more effective therapies and vaccines to improve health among people living with HIV (PLWH). In this paper, we review KIR diversity, the role of KIR immunogenetic variation in the human host response to HIV, discuss current perspectives on the studies to assess the relationship between KIR diversity and the HIV disease continuum, and suggest future research prospects.https://doi.org/10.1186/s41231-023-00141-zKiller cell immunoglobulin-like receptors (KIR)DiversityHuman immune deficiency virus (HIV)Bioinformatics |
spellingShingle | John Mukisa Marion Amujal Obondo J. Sande Moses L. Joloba Daudi Jjingo David P. Kateete Graeme Mardon Mogomotsi Matshaba Neil Hanchard Jill A. Hollenbach Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations Translational Medicine Communications Killer cell immunoglobulin-like receptors (KIR) Diversity Human immune deficiency virus (HIV) Bioinformatics |
title | Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations |
title_full | Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations |
title_fullStr | Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations |
title_full_unstemmed | Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations |
title_short | Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations |
title_sort | killer cell immunoglobulin receptor diversity and its relevance in the human host s response to hiv infection in african populations |
topic | Killer cell immunoglobulin-like receptors (KIR) Diversity Human immune deficiency virus (HIV) Bioinformatics |
url | https://doi.org/10.1186/s41231-023-00141-z |
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