Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years.
A longitudinal study was conducted to investigate the relation between a polymorphism in the vitamin D receptor (VDR) gene and changes in bone mineral density (BMD) and quantitative ultrasound of the phalanges (QUS) over a five-year period. The subjects were 456 postmenopausal women with osteoporosi...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4579091?pdf=render |
_version_ | 1818435209704505344 |
---|---|
author | Maria Pedrera-Canal Jose M Moran Vicente Vera Raul Roncero-Martin Jesus M Lavado-Garcia Ignacio Aliaga Juan D Pedrera-Zamorano |
author_facet | Maria Pedrera-Canal Jose M Moran Vicente Vera Raul Roncero-Martin Jesus M Lavado-Garcia Ignacio Aliaga Juan D Pedrera-Zamorano |
author_sort | Maria Pedrera-Canal |
collection | DOAJ |
description | A longitudinal study was conducted to investigate the relation between a polymorphism in the vitamin D receptor (VDR) gene and changes in bone mineral density (BMD) and quantitative ultrasound of the phalanges (QUS) over a five-year period. The subjects were 456 postmenopausal women with osteoporosis undergoing treatment, aged 59.95±7.97 years (mean±standard deviation [SD]) at baseline. BMD was measured at the hips and lumbar spine by dual-energy X-ray absorptiometry, and QUS was measured by means of amplitude-dependent speed of sound (Ad-SoS) at the phalanges. Lifestyle information was obtained via a questionnaire. The genotype frequencies of the BsmI (rs1544410) gene polymorphism were 29.4%, 47.1%, and 23.5% for bb, Bb, and BB, respectively. After five years, BMD (annual change in %/year) at the femoral neck (FN) showed a significant modification based on the rs1544410 genotype (BB vs Bb); there was an overall decrease in bone mass (-0.70±2.79%/year; P = 0.025). An analysis of covariance with adjustments for age, weight, height, percentage of weight change per year, baseline BMD and calcium intake showed that the observed associations were no longer significant (P = 0.429). No significant associations were found between the QUS measurements and the rs1544410 genotype after the five-year period. Our study limitations includes lack of information about type and length of duration of the osteoporosis treatment. Our results indicate that rs1544410 polymorphisms do not account significantly for the changes in bone mass in Spanish women with osteoporosis undergoing treatment. |
first_indexed | 2024-12-14T16:49:15Z |
format | Article |
id | doaj.art-7b35bdb5799c49b0b6645d1b4ce33303 |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-12-14T16:49:15Z |
publishDate | 2015-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-7b35bdb5799c49b0b6645d1b4ce333032022-12-21T22:54:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013860610.1371/journal.pone.0138606Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years.Maria Pedrera-CanalJose M MoranVicente VeraRaul Roncero-MartinJesus M Lavado-GarciaIgnacio AliagaJuan D Pedrera-ZamoranoA longitudinal study was conducted to investigate the relation between a polymorphism in the vitamin D receptor (VDR) gene and changes in bone mineral density (BMD) and quantitative ultrasound of the phalanges (QUS) over a five-year period. The subjects were 456 postmenopausal women with osteoporosis undergoing treatment, aged 59.95±7.97 years (mean±standard deviation [SD]) at baseline. BMD was measured at the hips and lumbar spine by dual-energy X-ray absorptiometry, and QUS was measured by means of amplitude-dependent speed of sound (Ad-SoS) at the phalanges. Lifestyle information was obtained via a questionnaire. The genotype frequencies of the BsmI (rs1544410) gene polymorphism were 29.4%, 47.1%, and 23.5% for bb, Bb, and BB, respectively. After five years, BMD (annual change in %/year) at the femoral neck (FN) showed a significant modification based on the rs1544410 genotype (BB vs Bb); there was an overall decrease in bone mass (-0.70±2.79%/year; P = 0.025). An analysis of covariance with adjustments for age, weight, height, percentage of weight change per year, baseline BMD and calcium intake showed that the observed associations were no longer significant (P = 0.429). No significant associations were found between the QUS measurements and the rs1544410 genotype after the five-year period. Our study limitations includes lack of information about type and length of duration of the osteoporosis treatment. Our results indicate that rs1544410 polymorphisms do not account significantly for the changes in bone mass in Spanish women with osteoporosis undergoing treatment.http://europepmc.org/articles/PMC4579091?pdf=render |
spellingShingle | Maria Pedrera-Canal Jose M Moran Vicente Vera Raul Roncero-Martin Jesus M Lavado-Garcia Ignacio Aliaga Juan D Pedrera-Zamorano Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. PLoS ONE |
title | Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. |
title_full | Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. |
title_fullStr | Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. |
title_full_unstemmed | Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. |
title_short | Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. |
title_sort | lack of influence of vitamin d receptor bsmi rs1544410 polymorphism on the rate of bone loss in a cohort of postmenopausal spanish women affected by osteoporosis and followed for five years |
url | http://europepmc.org/articles/PMC4579091?pdf=render |
work_keys_str_mv | AT mariapedreracanal lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears AT josemmoran lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears AT vicentevera lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears AT raulronceromartin lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears AT jesusmlavadogarcia lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears AT ignacioaliaga lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears AT juandpedrerazamorano lackofinfluenceofvitamindreceptorbsmirs1544410polymorphismontherateofbonelossinacohortofpostmenopausalspanishwomenaffectedbyosteoporosisandfollowedforfiveyears |