Linking immunity and hematopoiesis by bone marrow T cell activity
Two different levels of control for bone marrow hematopoiesis are believed to exist. On the one hand, normal blood cell distribution is believed to be maintained in healthy subjects by an "innate" hematopoietic activity, i.e., a basal intrinsic bone marrow activity. On the other hand, an &...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
2005-10-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000004 |
| _version_ | 1819125885069950976 |
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| author | J.P. Monteiro A. Bonomo |
| author_facet | J.P. Monteiro A. Bonomo |
| author_sort | J.P. Monteiro |
| collection | DOAJ |
| description | Two different levels of control for bone marrow hematopoiesis are believed to exist. On the one hand, normal blood cell distribution is believed to be maintained in healthy subjects by an "innate" hematopoietic activity, i.e., a basal intrinsic bone marrow activity. On the other hand, an "adaptive" hematopoietic state develops in response to stress-induced stimulation. This adaptive hematopoiesis targets specific lineage amplification depending on the nature of the stimuli. Unexpectedly, recent data have shown that what we call "normal hematopoiesis" is a stress-induced state maintained by activated bone marrow CD4+ T cells. This T cell population includes a large number of recently stimulated cells in normal mice whose priming requires the presence of the cognate antigens. In the absence of CD4+ T cells or their cognate antigens, hematopoiesis is maintained at low levels. In this review, we summarize current knowledge on T cell biology, which could explain how CD4+ T cells can help hematopoiesis, how they are primed in mice that were not intentionally immunized, and what maintains them activated in the bone marrow. |
| first_indexed | 2024-12-22T07:47:14Z |
| format | Article |
| id | doaj.art-7b3808efa75e4947b4ef44dcef0d4ca2 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-22T07:47:14Z |
| publishDate | 2005-10-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-7b3808efa75e4947b4ef44dcef0d4ca22022-12-21T18:33:36ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2005-10-0138101475148610.1590/S0100-879X2005001000004Linking immunity and hematopoiesis by bone marrow T cell activityJ.P. MonteiroA. BonomoTwo different levels of control for bone marrow hematopoiesis are believed to exist. On the one hand, normal blood cell distribution is believed to be maintained in healthy subjects by an "innate" hematopoietic activity, i.e., a basal intrinsic bone marrow activity. On the other hand, an "adaptive" hematopoietic state develops in response to stress-induced stimulation. This adaptive hematopoiesis targets specific lineage amplification depending on the nature of the stimuli. Unexpectedly, recent data have shown that what we call "normal hematopoiesis" is a stress-induced state maintained by activated bone marrow CD4+ T cells. This T cell population includes a large number of recently stimulated cells in normal mice whose priming requires the presence of the cognate antigens. In the absence of CD4+ T cells or their cognate antigens, hematopoiesis is maintained at low levels. In this review, we summarize current knowledge on T cell biology, which could explain how CD4+ T cells can help hematopoiesis, how they are primed in mice that were not intentionally immunized, and what maintains them activated in the bone marrow.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000004T cellHematopoiesisInnate immunityAdaptive immunityBone marrowImmunological memory |
| spellingShingle | J.P. Monteiro A. Bonomo Linking immunity and hematopoiesis by bone marrow T cell activity Brazilian Journal of Medical and Biological Research T cell Hematopoiesis Innate immunity Adaptive immunity Bone marrow Immunological memory |
| title | Linking immunity and hematopoiesis by bone marrow T cell activity |
| title_full | Linking immunity and hematopoiesis by bone marrow T cell activity |
| title_fullStr | Linking immunity and hematopoiesis by bone marrow T cell activity |
| title_full_unstemmed | Linking immunity and hematopoiesis by bone marrow T cell activity |
| title_short | Linking immunity and hematopoiesis by bone marrow T cell activity |
| title_sort | linking immunity and hematopoiesis by bone marrow t cell activity |
| topic | T cell Hematopoiesis Innate immunity Adaptive immunity Bone marrow Immunological memory |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000004 |
| work_keys_str_mv | AT jpmonteiro linkingimmunityandhematopoiesisbybonemarrowtcellactivity AT abonomo linkingimmunityandhematopoiesisbybonemarrowtcellactivity |