Atypical presentation of syphilis: Rapidly progressive glomerulonephritis
Abstract Syphilis is a sexually transmitted disease with a wide range of clinical manifestations. With the recent worldwide resurgence of syphilis, it is imperative to recognize various presentations of this great imitator. Renal syphilis is rare and most commonly present as nephrotic range proteinu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.6864 |
| _version_ | 1811162509042778112 |
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| author | Semir Abdi Usmael Tesfay Atsbaha Gebremedhin |
| author_facet | Semir Abdi Usmael Tesfay Atsbaha Gebremedhin |
| author_sort | Semir Abdi Usmael |
| collection | DOAJ |
| description | Abstract Syphilis is a sexually transmitted disease with a wide range of clinical manifestations. With the recent worldwide resurgence of syphilis, it is imperative to recognize various presentations of this great imitator. Renal syphilis is rare and most commonly present as nephrotic range proteinuria associated with pathological features of membranous glomerulonephritis. Rapidly progressive glomerulonephritis (RPGN) is a rare and atypical form of renal syphilis. A 50‐year‐old Ethiopian woman presented with periorbital swelling, hematuria, proteinuria, and rapidly progressive renal failure. Rapid plasma reagin and confirmatory Treponema pallidum hemagglutination (TPHA) tests were reactive. Treatment with a weekly Benzathine penicillin for 3 weeks resulted in a rapid return of renal function to baseline, with the increasing rate of new syphilis, clinicians should be mindful of the various renal manifestation of syphilis. This case highlights the significance of considering syphilis as a reversible cause in any patient presenting with a clinical feature suggestive of RPGN. |
| first_indexed | 2024-04-10T06:30:52Z |
| format | Article |
| id | doaj.art-7b395357b3534dbe9c298a635bb5f02e |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-10T06:30:52Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-7b395357b3534dbe9c298a635bb5f02e2023-03-01T07:50:57ZengWileyClinical Case Reports2050-09042023-01-01111n/an/a10.1002/ccr3.6864Atypical presentation of syphilis: Rapidly progressive glomerulonephritisSemir Abdi Usmael0Tesfay Atsbaha Gebremedhin1Internal Medicine Department College of Health and Medical Sciences, Haramaya University Harar EthiopiaInternal Medicine Department College of Health and Medical Sciences, Haramaya University Harar EthiopiaAbstract Syphilis is a sexually transmitted disease with a wide range of clinical manifestations. With the recent worldwide resurgence of syphilis, it is imperative to recognize various presentations of this great imitator. Renal syphilis is rare and most commonly present as nephrotic range proteinuria associated with pathological features of membranous glomerulonephritis. Rapidly progressive glomerulonephritis (RPGN) is a rare and atypical form of renal syphilis. A 50‐year‐old Ethiopian woman presented with periorbital swelling, hematuria, proteinuria, and rapidly progressive renal failure. Rapid plasma reagin and confirmatory Treponema pallidum hemagglutination (TPHA) tests were reactive. Treatment with a weekly Benzathine penicillin for 3 weeks resulted in a rapid return of renal function to baseline, with the increasing rate of new syphilis, clinicians should be mindful of the various renal manifestation of syphilis. This case highlights the significance of considering syphilis as a reversible cause in any patient presenting with a clinical feature suggestive of RPGN.https://doi.org/10.1002/ccr3.6864case reportEthiopiahematuriarapidly progressive glomerulonephritissyphilis |
| spellingShingle | Semir Abdi Usmael Tesfay Atsbaha Gebremedhin Atypical presentation of syphilis: Rapidly progressive glomerulonephritis Clinical Case Reports case report Ethiopia hematuria rapidly progressive glomerulonephritis syphilis |
| title | Atypical presentation of syphilis: Rapidly progressive glomerulonephritis |
| title_full | Atypical presentation of syphilis: Rapidly progressive glomerulonephritis |
| title_fullStr | Atypical presentation of syphilis: Rapidly progressive glomerulonephritis |
| title_full_unstemmed | Atypical presentation of syphilis: Rapidly progressive glomerulonephritis |
| title_short | Atypical presentation of syphilis: Rapidly progressive glomerulonephritis |
| title_sort | atypical presentation of syphilis rapidly progressive glomerulonephritis |
| topic | case report Ethiopia hematuria rapidly progressive glomerulonephritis syphilis |
| url | https://doi.org/10.1002/ccr3.6864 |
| work_keys_str_mv | AT semirabdiusmael atypicalpresentationofsyphilisrapidlyprogressiveglomerulonephritis AT tesfayatsbahagebremedhin atypicalpresentationofsyphilisrapidlyprogressiveglomerulonephritis |