Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample
Abstract Chronic comorbid conditions are common in adults with asthma, and some may influence a patient’s asthma exacerbation risk. We explored associations between eighteen chronic comorbid conditions and asthma exacerbation occurrence in adults with asthma in a cross-sectional study nested within...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | npj Primary Care Respiratory Medicine |
| Online Access: | https://doi.org/10.1038/s41533-023-00350-x |
| _version_ | 1797578103661264896 |
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| author | Emma Baljet Hilde Luijks Lisette van den Bemt Tjard R. Schermer |
| author_facet | Emma Baljet Hilde Luijks Lisette van den Bemt Tjard R. Schermer |
| author_sort | Emma Baljet |
| collection | DOAJ |
| description | Abstract Chronic comorbid conditions are common in adults with asthma, and some may influence a patient’s asthma exacerbation risk. We explored associations between eighteen chronic comorbid conditions and asthma exacerbation occurrence in adults with asthma in a cross-sectional study nested within a cohort study using data from the two-yearly US National Health and Nutrition Examination Survey (NHANES) program. Data of 2387 adults with self-reported doctor-diagnosed current asthma from the 2007 to 2018 NHANES surveys were selected. Investigated chronic comorbidities were: angina pectoris; congestive heart failure; coronary heart disease; depression; diabetes mellitus; soft and hard drug use; gastroesophageal reflux; gout; history of heart attack; history of stroke; hypercholesterolemia; hypertension; kidney failure; liver conditions; obesity; rheumatoid arthritis; and thyroid problems. Outcome was defined as asthma exacerbation category: no, moderate, or severe exacerbation(s) in the past year. Ordinal logistic regression analysis with correction for potential confounders was used to estimate odds ratios (OR) for moderate or severe exacerbations. Observed associations with increased severe asthma exacerbation occurrence were: obesity (OR = 1.67; 95% confidence interval 1.24, 2.26), and rheumatoid arthritis (OR = 1.55; 1.04, 2.30). History of stroke (OR = 1.95; 1.22, 3.11) and rheumatoid arthritis (OR = 1.33; 1.00, 1.75) showed associations with increased moderate exacerbation occurrence. Age-stratified analysis showed soft drug use, obesity, depression, thyroid problems, and rheumatoid arthritis to be associated with moderate and/or severe exacerbation occurrence in one or more 10-year age strata. In conclusion, several chronic comorbid conditions were associated with asthma exacerbation occurrence, which confirms but also complements previous studies. Our observations contribute to understanding exacerbation risk estimation and, ultimately, personalized asthma management. |
| first_indexed | 2024-03-10T22:17:42Z |
| format | Article |
| id | doaj.art-7b39e223e5b84d5e8460519bf7dd9203 |
| institution | Directory Open Access Journal |
| issn | 2055-1010 |
| language | English |
| last_indexed | 2024-03-10T22:17:42Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Primary Care Respiratory Medicine |
| spelling | doaj.art-7b39e223e5b84d5e8460519bf7dd92032023-11-19T12:23:40ZengNature Portfolionpj Primary Care Respiratory Medicine2055-10102023-08-013311910.1038/s41533-023-00350-xChronic comorbid conditions and asthma exacerbation occurrence in a general population sampleEmma Baljet0Hilde Luijks1Lisette van den Bemt2Tjard R. Schermer3Department of Primary and Community Care, Radboud Institute for Health Sciences, Radboud University Medical CenterDepartment of Primary and Community Care, Radboud Institute for Health Sciences, Radboud University Medical CenterDepartment of Primary and Community Care, Radboud Institute for Health Sciences, Radboud University Medical CenterDepartment of Primary and Community Care, Radboud Institute for Health Sciences, Radboud University Medical CenterAbstract Chronic comorbid conditions are common in adults with asthma, and some may influence a patient’s asthma exacerbation risk. We explored associations between eighteen chronic comorbid conditions and asthma exacerbation occurrence in adults with asthma in a cross-sectional study nested within a cohort study using data from the two-yearly US National Health and Nutrition Examination Survey (NHANES) program. Data of 2387 adults with self-reported doctor-diagnosed current asthma from the 2007 to 2018 NHANES surveys were selected. Investigated chronic comorbidities were: angina pectoris; congestive heart failure; coronary heart disease; depression; diabetes mellitus; soft and hard drug use; gastroesophageal reflux; gout; history of heart attack; history of stroke; hypercholesterolemia; hypertension; kidney failure; liver conditions; obesity; rheumatoid arthritis; and thyroid problems. Outcome was defined as asthma exacerbation category: no, moderate, or severe exacerbation(s) in the past year. Ordinal logistic regression analysis with correction for potential confounders was used to estimate odds ratios (OR) for moderate or severe exacerbations. Observed associations with increased severe asthma exacerbation occurrence were: obesity (OR = 1.67; 95% confidence interval 1.24, 2.26), and rheumatoid arthritis (OR = 1.55; 1.04, 2.30). History of stroke (OR = 1.95; 1.22, 3.11) and rheumatoid arthritis (OR = 1.33; 1.00, 1.75) showed associations with increased moderate exacerbation occurrence. Age-stratified analysis showed soft drug use, obesity, depression, thyroid problems, and rheumatoid arthritis to be associated with moderate and/or severe exacerbation occurrence in one or more 10-year age strata. In conclusion, several chronic comorbid conditions were associated with asthma exacerbation occurrence, which confirms but also complements previous studies. Our observations contribute to understanding exacerbation risk estimation and, ultimately, personalized asthma management.https://doi.org/10.1038/s41533-023-00350-x |
| spellingShingle | Emma Baljet Hilde Luijks Lisette van den Bemt Tjard R. Schermer Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample npj Primary Care Respiratory Medicine |
| title | Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample |
| title_full | Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample |
| title_fullStr | Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample |
| title_full_unstemmed | Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample |
| title_short | Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample |
| title_sort | chronic comorbid conditions and asthma exacerbation occurrence in a general population sample |
| url | https://doi.org/10.1038/s41533-023-00350-x |
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