Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle

Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle

Regenerative capacity of skeletal muscle declines with age, the cause of which remains largely unknown. We investigated extracellular matrix (ECM) proteins and their regulators during early regeneration timepoints to define a link between aberrant ECM remodeling, and impaired aged muscle regeneratio...

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Bibliographic Details
Main Authors: Fasih Ahmad Rahman, Sarah Anne Angus, Kyle Stokes, Phillip Karpowicz, Matthew Paul Krause
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
skeletal muscle
regeneration
extracellular matrix
macrophage
plasminogen activator inhibitor-1
aging
Online Access:https://www.mdpi.com/1422-0067/21/13/4575

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