Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study
Background: Several studies have investigated the differences in salivary parameters and microbial composition between diabetic and non-diabetic patients, however, specific differences are still not clear mainly due to the effects of confounder. Aim: The aim of this case-control study was to ev...
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| Format: | Article |
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Universidade Estadual Paulista
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| Series: | Revista de Odontologia da UNESP |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772014000300196&lng=en&tlng=en |
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| author | José Roberto CORTELLI Regina Márcia Serpa PINHEIRO Fernando de Oliveira COSTA Davi Romeiro AQUINO Suzane A RASLAN Sheila Cavalca CORTELLI |
| author_facet | José Roberto CORTELLI Regina Márcia Serpa PINHEIRO Fernando de Oliveira COSTA Davi Romeiro AQUINO Suzane A RASLAN Sheila Cavalca CORTELLI |
| author_sort | José Roberto CORTELLI |
| collection | DOAJ |
| description | Background: Several studies have investigated the differences in salivary parameters and microbial composition between diabetic and non-diabetic patients, however, specific differences are still not clear mainly due to the effects of confounder. Aim: The aim of this case-control study was to evaluate the salivary and microbial parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus. Material and method: This case-control study included 60 chronic periodontitis subjects, 30 diabetics (case group) and 30 non-diabetics (control group), paired according to periodontitis severity, gender and age. Stimulated whole saliva was collected from all volunteers to measure the salivary pH and the salivary flow rate. Bacterial samples were collected with paper points from periodontal sites showing the deepest periodontal pocket depth associated with the highest clinical attachment loss. The frequency of A. actinomycetemcomitans, P. intermedia, P. gingivalis, T. forsythia and C. rectus was evaluated by PCR. Data was statistically analyzed by Student's t, Mann-Whitney and Chi-square (p<0.05). Result: Diabetic subjects showed higher salivary glucose levels and lower stimulated flow rates in comparison to non-diabetic controls. P. gingivalis and T. forsythia were the most frequent pathogens (p<0.05). Bacterial frequency did not differ between case and control groups. Conclusion: Diabetes status influenced salivary glucose levels and flow rate. Within the same severity of chronic periodontitis, diabetic subjects did not show higher frequency of periodontal pathogens in comparison to their paired controls. |
| first_indexed | 2024-12-10T20:53:52Z |
| format | Article |
| id | doaj.art-7b3e8d162146444288b1c924ea7aaa5b |
| institution | Directory Open Access Journal |
| issn | 1807-2577 |
| language | English |
| last_indexed | 2024-12-10T20:53:52Z |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Revista de Odontologia da UNESP |
| spelling | doaj.art-7b3e8d162146444288b1c924ea7aaa5b2022-12-22T01:34:00ZengUniversidade Estadual PaulistaRevista de Odontologia da UNESP1807-257743319620210.1590/rou.2014.030S1807-25772014000300196Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control studyJosé Roberto CORTELLIRegina Márcia Serpa PINHEIROFernando de Oliveira COSTADavi Romeiro AQUINOSuzane A RASLANSheila Cavalca CORTELLIBackground: Several studies have investigated the differences in salivary parameters and microbial composition between diabetic and non-diabetic patients, however, specific differences are still not clear mainly due to the effects of confounder. Aim: The aim of this case-control study was to evaluate the salivary and microbial parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus. Material and method: This case-control study included 60 chronic periodontitis subjects, 30 diabetics (case group) and 30 non-diabetics (control group), paired according to periodontitis severity, gender and age. Stimulated whole saliva was collected from all volunteers to measure the salivary pH and the salivary flow rate. Bacterial samples were collected with paper points from periodontal sites showing the deepest periodontal pocket depth associated with the highest clinical attachment loss. The frequency of A. actinomycetemcomitans, P. intermedia, P. gingivalis, T. forsythia and C. rectus was evaluated by PCR. Data was statistically analyzed by Student's t, Mann-Whitney and Chi-square (p<0.05). Result: Diabetic subjects showed higher salivary glucose levels and lower stimulated flow rates in comparison to non-diabetic controls. P. gingivalis and T. forsythia were the most frequent pathogens (p<0.05). Bacterial frequency did not differ between case and control groups. Conclusion: Diabetes status influenced salivary glucose levels and flow rate. Within the same severity of chronic periodontitis, diabetic subjects did not show higher frequency of periodontal pathogens in comparison to their paired controls.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772014000300196&lng=en&tlng=enSalivabacteriachronic periodontitisdiabetes mellitus |
| spellingShingle | José Roberto CORTELLI Regina Márcia Serpa PINHEIRO Fernando de Oliveira COSTA Davi Romeiro AQUINO Suzane A RASLAN Sheila Cavalca CORTELLI Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study Revista de Odontologia da UNESP Saliva bacteria chronic periodontitis diabetes mellitus |
| title | Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study |
| title_full | Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study |
| title_fullStr | Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study |
| title_full_unstemmed | Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study |
| title_short | Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: a case-control study |
| title_sort | salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus a case control study |
| topic | Saliva bacteria chronic periodontitis diabetes mellitus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772014000300196&lng=en&tlng=en |
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