Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice
Abstract Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also which we should inhibit, in order to achieve a specific goal. The encoding of such c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-38025-3 |
| _version_ | 1797840939787485184 |
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| author | Tadaaki Nishioka Suthinee Attachaipanich Kosuke Hamaguchi Michael Lazarus Alban de Kerchove d’Exaerde Tom Macpherson Takatoshi Hikida |
| author_facet | Tadaaki Nishioka Suthinee Attachaipanich Kosuke Hamaguchi Michael Lazarus Alban de Kerchove d’Exaerde Tom Macpherson Takatoshi Hikida |
| author_sort | Tadaaki Nishioka |
| collection | DOAJ |
| description | Abstract Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also which we should inhibit, in order to achieve a specific goal. The encoding of such cue-outcome associations, as well as the performance of cue-guided choice behavior, is thought to involve dopamine D1 and D2 receptor-expressing medium spiny neurons (D1-/D2-MSNs) of the nucleus accumbens (NAc). Here, using a visual discrimination task in male mice, we assessed the role of NAc D1-/D2-MSNs in cue-guided inhibition of inappropriate responding. Cell-type specific neuronal silencing and in-vivo imaging revealed NAc D2-MSNs to contribute to inhibiting behavioral responses, with activation of NAc D2-MSNs following response errors playing an important role in optimizing future choice behavior. Our findings indicate that error-signaling by NAc D2-MSNs contributes to the ability to use environmental cues to inhibit inappropriate behavior. |
| first_indexed | 2024-04-09T16:22:56Z |
| format | Article |
| id | doaj.art-7b3fa6a3623f4a96ab59226b28a5ce69 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T16:22:56Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7b3fa6a3623f4a96ab59226b28a5ce692023-04-23T11:22:35ZengNature PortfolioNature Communications2041-17232023-04-0114111510.1038/s41467-023-38025-3Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in miceTadaaki Nishioka0Suthinee Attachaipanich1Kosuke Hamaguchi2Michael Lazarus3Alban de Kerchove d’Exaerde4Tom Macpherson5Takatoshi Hikida6Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka UniversityLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka UniversityDepartment of Biological Sciences, Graduate School of Medicine, Kyoto UniversityInternational Institute for Integrative Sleep Medicine (WPI-IIIS) and Faculty of Medicine, University of TsukubaNeurophysiology Lab, ULB Neuroscience Institute, Université Libre de BruxellesLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka UniversityLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka UniversityAbstract Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also which we should inhibit, in order to achieve a specific goal. The encoding of such cue-outcome associations, as well as the performance of cue-guided choice behavior, is thought to involve dopamine D1 and D2 receptor-expressing medium spiny neurons (D1-/D2-MSNs) of the nucleus accumbens (NAc). Here, using a visual discrimination task in male mice, we assessed the role of NAc D1-/D2-MSNs in cue-guided inhibition of inappropriate responding. Cell-type specific neuronal silencing and in-vivo imaging revealed NAc D2-MSNs to contribute to inhibiting behavioral responses, with activation of NAc D2-MSNs following response errors playing an important role in optimizing future choice behavior. Our findings indicate that error-signaling by NAc D2-MSNs contributes to the ability to use environmental cues to inhibit inappropriate behavior.https://doi.org/10.1038/s41467-023-38025-3 |
| spellingShingle | Tadaaki Nishioka Suthinee Attachaipanich Kosuke Hamaguchi Michael Lazarus Alban de Kerchove d’Exaerde Tom Macpherson Takatoshi Hikida Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice Nature Communications |
| title | Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice |
| title_full | Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice |
| title_fullStr | Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice |
| title_full_unstemmed | Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice |
| title_short | Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice |
| title_sort | error related signaling in nucleus accumbens d2 receptor expressing neurons guides inhibition based choice behavior in mice |
| url | https://doi.org/10.1038/s41467-023-38025-3 |
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