NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B...

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Bibliographic Details
Main Authors:	Benjamin E. Gewurz, Ina Ersing, Katharina Bernhardt
Format:	Article
Language:	English
Published:	MDPI AG 2013-06-01
Series:	Viruses
Subjects:	herpesvirus apoptosis cancer innate immunity transformation integral membrane protein signal transduction proliferation ubiquitin lymphoma oncogene
Online Access:	http://www.mdpi.com/1999-4915/5/6/1587

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