A High-Throughput NMR Method for Lipoprotein-X Quantification

A High-Throughput NMR Method for Lipoprotein-X Quantification

Lipoprotein X (LP-X) is an abnormal cholesterol-rich lipoprotein particle that accumulates in patients with cholestatic liver disease and familial lecithin–cholesterol acyltransferase deficiency (FLD). Because there are no high-throughput diagnostic tests for its detection, a proton nuclear magnetic...

Full description

Bibliographic Details
Main Authors:	Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Lita A. Freeman, Edward B. Neufeld, Maureen L. Sampson, Rafael Zubirán, Anna Wolska, Alan T. Remaley, James D. Otvos, Margery A. Connelly
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	Molecules
Subjects:	lipoprotein-X LCAT deficiency cholestasis hypercholesterolemia
Online Access:	https://www.mdpi.com/1420-3049/29/3/564

Similar Items

A Simple Fluorescent Cholesterol Labeling Method to Cryoprotect and Detect Plasma Lipoprotein-X
by: Edward B. Neufeld, et al.
Published: (2022-08-01)

Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay
by: Shimpi Bedi, et al.
Published: (2020-09-01)

LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis
by: Marcelo J. A. Amar, et al.
Published: (2020-02-01)

Case report: Unusual and extremely severe lipoprotein X-mediated hypercholesterolemia in extrahepatic pediatric cholestasis
by: Rossella Colantuono, et al.
Published: (2022-08-01)

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
by: Kelly A Manthei, et al.
Published: (2018-11-01)

Phospholipid transfer protein activity in two cholestatic patients
by: Eliana Cotta de Faria, et al.

Accuracy and Clinical Impact of Estimating Low-Density Lipoprotein-Cholesterol at High and Low Levels by Different Equations
by: Maureen Sampson, et al.
Published: (2022-12-01)

Lipoprotein lipase deficiency and CETP in streptozotocin-treated apoB-expressing mice
by: Yuko Kako, et al.
Published: (2002-06-01)

LECITHIN: CHOLESTEROL ACYLTRANSFERASE ACTIVITY IS DECREASED IN TYPE 2 DIABETES MELLITUS
by: A. Ghanei, et al.
Published: (2007-09-01)

LECITHIN: CHOLESTEROL ACYLTRANSFERASE ACTIVITY IS DECREASED IN TYPE 2 DIABETES MELLITUS
by: A. Ghanei, et al.
Published: (2007-12-01)

Impact of Sepsis on High-Density Lipoprotein Metabolism
by: Alexander C. Reisinger, et al.
Published: (2022-01-01)

Effects of highly purified sardine proteins on lipid peroxidation and reverse cholesterol transport in rats fed a cholesterol-rich diet
by: Sabrine Louala, et al.
Published: (2011-10-01)

Transmission of two novel mutations in a pedigree with familial lecithin:cholesterol acyltransferase deficiency: structure–function relationships and studies in a compound heterozygous proband
by: George Argyropoulos, et al.
Published: (1998-09-01)

The NIH Lipo-COVID Study: A Pilot NMR Investigation of Lipoprotein Subfractions and Other Metabolites in Patients with Severe COVID-19
by: Rami A. Ballout, et al.
Published: (2021-08-01)

Lipoprotein metabolism in familial hypercholesterolemia
by: Kévin Chemello, et al.
Published: (2021-01-01)

Role of lipoprotein apheresis in the management of familial hypercholesterolemia
by: Shamanna Seshadri Iyengar, et al.
Published: (2021-01-01)

Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses
by: Julia T. Stadler, et al.
Published: (2022-04-01)

Abnormal Lipoproteins Trigger Oxidative Stress-Mediated Apoptosis of Renal Cells in LCAT Deficiency
by: Monica Gomaraschi, et al.
Published: (2023-07-01)

Severe Hypercholesterolemia Mediated by Lipoprotein X in an Immunosuppressed Patient: A Case Report
by: Cristiana Sequeira, et al.
Published: (2022-10-01)

Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein
by: Ewa Wieczorek, et al.
Published: (2021-04-01)

Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study
by: Katsuaki Yokoyama, et al.
Published: (2018-12-01)

Subclinical Hyperthyroidism: Status of the Cholesterol Transfers to HDL and Other Parameters Related to Lipoprotein Metabolism in Patients Submitted to Thyroidectomy for Thyroid Cancer
by: Gilbert A. Sigal, et al.
Published: (2020-04-01)

Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats
by: Mamata Pochhi
Published: (2019-07-01)

Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency
by: Margareta Fistrek Prlic, et al.
Published: (2022-08-01)

A new enzyme-linked immunosorbent assay with two monoclonal antibodies to specific epitopes measures human lecithin-cholesterol acyltransferase
by: Kiichiro Kobori, et al.
Published: (2002-02-01)

Measurment of rhesus monkey (Macaca mulatta) apolipoprotein B in serum by radioimmunoassay: comparison of immunoreactivities of rhesus and human low density lipoproteins
by: J B Karlin, et al.
Published: (1978-02-01)

Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome
by: Gabriele Mocciaro, et al.
Published: (2022-06-01)

Trans unsaturated fatty acids inhibit lecithin: cholesterol acyltransferase and alter its positional specificity1
by: Papasani V. Subbaiah, et al.
Published: (1998-07-01)

Hypoglycemic and antihyperlipidemic effect of aqueous leaves extract of Ficus Religiosa in alloxan induced diabetic rats
by: Mamata Pochhi
Published: (2017-03-01)

LIPOPROTEIN(A) MEANING AS AN ADDITIONAL MARKER OF CARDIOVASCULAR RISK IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA
by: V. A. Korneva, et al.
Published: (2016-06-01)

Systematic Review of Low‐Density Lipoprotein Cholesterol Apheresis for the Treatment of Familial Hypercholesterolemia
by: Anthony Wang, et al.
Published: (2016-07-01)

Detection of Lipoprotein X (LpX): A challenge in patients with severe hypercholesterolaemia
by: Ćwiklińska Agnieszka, et al.
Published: (2020-01-01)

Characterization of Polyvascular Disease in Heterozygous Familial Hypercholesterolemia: Its Association With Circulating Lipoprotein(a) Levels
by: Sayaka Funabashi, et al.
Published: (2022-08-01)

The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes
by: Trevor J. Orchard, et al.
Published: (2017-06-01)

The Effect of Melinjo Peel Extract in Activity of Lipoprotein Lipase Enzym of The Rats Fed a Hypercholesterolemia Diet
by: Athira Demitri
Published: (2018-12-01)

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia
by: Elena Olmastroni, et al.
Published: (2023-05-01)

High-Density Lipoprotein Changes in Alzheimer’s Disease Are <i>APOE</i> Genotype-Specific
by: Brian V. Hong, et al.
Published: (2022-06-01)

Clinical characteristics associated with elevated levels of lipoprotein(a) in patients with vascular risk
by: Rubio-Serrano Javier, et al.
Published: (2023-12-01)

Familial Hypercholesterolemia and Elevated Lipoprotein(a): Cascade Testing and Other Implications for Contextual Models of Care
by: Wann Jia Loh, et al.
Published: (2022-04-01)

Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations
by: Ciro Acosta S, et al.
Published: (2024-02-01)