Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study
The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/6/1233 |
| _version_ | 1797241733333909504 |
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| author | Archana Vadiraj Malagi Xinqi Li Na Zhang Yucen Liu Yuheng Huang Fardad Michael Serry Ziyang Long Chia-Chi Yang Yujie Shan Yubin Cai Jeremy Zepeda Nader Binesh Debiao Li Hsin-Jung Yang Hui Han |
| author_facet | Archana Vadiraj Malagi Xinqi Li Na Zhang Yucen Liu Yuheng Huang Fardad Michael Serry Ziyang Long Chia-Chi Yang Yujie Shan Yubin Cai Jeremy Zepeda Nader Binesh Debiao Li Hsin-Jung Yang Hui Han |
| author_sort | Archana Vadiraj Malagi |
| collection | DOAJ |
| description | The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF head coil (32-ch RF receive and 51-ch shim) for 3D-MRSI improvement. We compared its shimming performance and 3D-MRSI brain coverages against the standard scanner shim (2nd-order spherical harmonic (SH) shim coils) and integrated parallel reception, excitation, and shimming (iPRES) 32-ch AC/DC head coil. We also simulated a theoretical 3rd-, 4th-, and 5th-order SH shim as a benchmark to assess the UNIfied shim–RF coil (UNIC) improvements. In this preliminary study, the whole-brain coverage was simulated by using B<sub>0</sub> field maps of twenty-four healthy human subjects (<i>n</i> = 24). Our results demonstrated that UNIC substantially improves brain field homogeneity, reducing whole-brain frequency standard deviations by 27% compared to the standard 2nd-order scanner shim and 17% compared to the iPRES shim. Moreover, UNIC enhances whole-brain coverage of 3D-MRSI by up to 34% compared to the standard 2nd-order scanner shim and up to 13% compared to the iPRES shim. UNIC markedly increases coverage in the prefrontal cortex by 147% and 47% and in the medial temporal lobe and temporal pole by 29% and 13%, respectively, at voxel resolutions of 1.4 cc and 0.09 cc for 3D-MRSI. Furthermore, UNIC effectively reduces variations in shim quality and brain coverage among different subjects compared to scanner shim and iPRES shim. Anticipated advancements in higher-order shimming (beyond 6th order) are expected via optimized designs using dimensionality reduction methods. |
| first_indexed | 2024-04-24T18:28:01Z |
| format | Article |
| id | doaj.art-7b4107a2a0cf4650b7a5ba27d42a1819 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-04-24T18:28:01Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7b4107a2a0cf4650b7a5ba27d42a18192024-03-27T13:30:11ZengMDPI AGCancers2072-66942024-03-01166123310.3390/cancers16061233Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary StudyArchana Vadiraj Malagi0Xinqi Li1Na Zhang2Yucen Liu3Yuheng Huang4Fardad Michael Serry5Ziyang Long6Chia-Chi Yang7Yujie Shan8Yubin Cai9Jeremy Zepeda10Nader Binesh11Debiao Li12Hsin-Jung Yang13Hui Han14Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Radiology, Weill Medical College of Cornell University, New York, NY 10065, USAThe spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF head coil (32-ch RF receive and 51-ch shim) for 3D-MRSI improvement. We compared its shimming performance and 3D-MRSI brain coverages against the standard scanner shim (2nd-order spherical harmonic (SH) shim coils) and integrated parallel reception, excitation, and shimming (iPRES) 32-ch AC/DC head coil. We also simulated a theoretical 3rd-, 4th-, and 5th-order SH shim as a benchmark to assess the UNIfied shim–RF coil (UNIC) improvements. In this preliminary study, the whole-brain coverage was simulated by using B<sub>0</sub> field maps of twenty-four healthy human subjects (<i>n</i> = 24). Our results demonstrated that UNIC substantially improves brain field homogeneity, reducing whole-brain frequency standard deviations by 27% compared to the standard 2nd-order scanner shim and 17% compared to the iPRES shim. Moreover, UNIC enhances whole-brain coverage of 3D-MRSI by up to 34% compared to the standard 2nd-order scanner shim and up to 13% compared to the iPRES shim. UNIC markedly increases coverage in the prefrontal cortex by 147% and 47% and in the medial temporal lobe and temporal pole by 29% and 13%, respectively, at voxel resolutions of 1.4 cc and 0.09 cc for 3D-MRSI. Furthermore, UNIC effectively reduces variations in shim quality and brain coverage among different subjects compared to scanner shim and iPRES shim. Anticipated advancements in higher-order shimming (beyond 6th order) are expected via optimized designs using dimensionality reduction methods.https://www.mdpi.com/2072-6694/16/6/12333Tmagnetic resonance spectroscopic imagingshim–RF head coilsarray coilslocal B<sub>0</sub> shimmingspherical harmonic (SH) |
| spellingShingle | Archana Vadiraj Malagi Xinqi Li Na Zhang Yucen Liu Yuheng Huang Fardad Michael Serry Ziyang Long Chia-Chi Yang Yujie Shan Yubin Cai Jeremy Zepeda Nader Binesh Debiao Li Hsin-Jung Yang Hui Han Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study Cancers 3T magnetic resonance spectroscopic imaging shim–RF head coils array coils local B<sub>0</sub> shimming spherical harmonic (SH) |
| title | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_full | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_fullStr | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_full_unstemmed | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_short | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_sort | enhancing whole brain magnetic field homogeneity for 3d magnetic resonance spectroscopic imaging with a novel unified coil a preliminary study |
| topic | 3T magnetic resonance spectroscopic imaging shim–RF head coils array coils local B<sub>0</sub> shimming spherical harmonic (SH) |
| url | https://www.mdpi.com/2072-6694/16/6/1233 |
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