HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
Abstract HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at the contact site forms the virological synapse. Additional cellular processes, such as nanotubes, filopodia, virus accumulation in endocytic or phagocytic compartments promote efficient viral propag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12977-018-0434-1 |
| _version_ | 1818318940634349568 |
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| author | Jérémy Dufloo Timothée Bruel Olivier Schwartz |
| author_facet | Jérémy Dufloo Timothée Bruel Olivier Schwartz |
| author_sort | Jérémy Dufloo |
| collection | DOAJ |
| description | Abstract HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at the contact site forms the virological synapse. Additional cellular processes, such as nanotubes, filopodia, virus accumulation in endocytic or phagocytic compartments promote efficient viral propagation. Cell-to-cell transmission allows immune evasion and likely contributes to HIV-1 spread in vivo. Anti-HIV-1 broadly neutralizing antibodies (bNAbs) defeat the majority of circulating viral strains by binding to the viral envelope glycoprotein (Env). Several bNAbs have entered clinical evaluation during the last years. It is thus important to understand their mechanism of action and to determine how they interact with infected cells. In experimental models, HIV-1 cell-to-cell transmission is sensitive to neutralization, but the effect of antibodies is often less marked than during cell-free infection. This may be due to differences in the conformation or accessibility of Env at the surface of virions and cells. In this review, we summarize the current knowledge on HIV-1 cell-to-cell transmission and discuss the role of bNAbs during this process. |
| first_indexed | 2024-12-13T10:01:12Z |
| format | Article |
| id | doaj.art-7b4207eb2bab4ad0b83ccdf758a0deed |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-13T10:01:12Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-7b4207eb2bab4ad0b83ccdf758a0deed2022-12-21T23:51:39ZengBMCRetrovirology1742-46902018-07-0115111410.1186/s12977-018-0434-1HIV-1 cell-to-cell transmission and broadly neutralizing antibodiesJérémy Dufloo0Timothée Bruel1Olivier Schwartz2Virus and Immunity Unit, Department of Virology, Institut PasteurVirus and Immunity Unit, Department of Virology, Institut PasteurVirus and Immunity Unit, Department of Virology, Institut PasteurAbstract HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at the contact site forms the virological synapse. Additional cellular processes, such as nanotubes, filopodia, virus accumulation in endocytic or phagocytic compartments promote efficient viral propagation. Cell-to-cell transmission allows immune evasion and likely contributes to HIV-1 spread in vivo. Anti-HIV-1 broadly neutralizing antibodies (bNAbs) defeat the majority of circulating viral strains by binding to the viral envelope glycoprotein (Env). Several bNAbs have entered clinical evaluation during the last years. It is thus important to understand their mechanism of action and to determine how they interact with infected cells. In experimental models, HIV-1 cell-to-cell transmission is sensitive to neutralization, but the effect of antibodies is often less marked than during cell-free infection. This may be due to differences in the conformation or accessibility of Env at the surface of virions and cells. In this review, we summarize the current knowledge on HIV-1 cell-to-cell transmission and discuss the role of bNAbs during this process.http://link.springer.com/article/10.1186/s12977-018-0434-1HIV-1bNAbsCell-to-cell transmissionNeutralization |
| spellingShingle | Jérémy Dufloo Timothée Bruel Olivier Schwartz HIV-1 cell-to-cell transmission and broadly neutralizing antibodies Retrovirology HIV-1 bNAbs Cell-to-cell transmission Neutralization |
| title | HIV-1 cell-to-cell transmission and broadly neutralizing antibodies |
| title_full | HIV-1 cell-to-cell transmission and broadly neutralizing antibodies |
| title_fullStr | HIV-1 cell-to-cell transmission and broadly neutralizing antibodies |
| title_full_unstemmed | HIV-1 cell-to-cell transmission and broadly neutralizing antibodies |
| title_short | HIV-1 cell-to-cell transmission and broadly neutralizing antibodies |
| title_sort | hiv 1 cell to cell transmission and broadly neutralizing antibodies |
| topic | HIV-1 bNAbs Cell-to-cell transmission Neutralization |
| url | http://link.springer.com/article/10.1186/s12977-018-0434-1 |
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