Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

Background and AimsImmunoregulatory checkpoint receptors (CR) contribute to the profound immunoparesis observed in alcohol-related liver disease (ALD) and in vitro neutralization of inhibitory-CRs TIM3/PD1 on anti-bacterial T-cells can rescue innate and adaptive anti-bacterial immunity. Recently des...

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Bibliographic Details
Main Authors: Antonio Riva, Elena Palma, Dhruti Devshi, Douglas Corrigall, Huyen Adams, Nigel Heaton, Krishna Menon, Melissa Preziosi, Ane Zamalloa, Rosa Miquel, Jennifer M. Ryan, Gavin Wright, Sarah Fairclough, Alexander Evans, Debbie Shawcross, Robert Schierwagen, Sabine Klein, Frank E. Uschner, Michael Praktiknjo, Krum Katzarov, Tanya Hadzhiolova, Slava Pavlova, Marieta Simonova, Jonel Trebicka, Roger Williams, Shilpa Chokshi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
TIM3
immune checkpoint
alcohol
biomarker
alcohol-related liver disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.632502/full

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