One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity

One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity

The use of the solvent engineering has been applied for controlling the resolution of lipase-catalyzed synthesis of β-aminoacids via Michael addition reactions. The strategy consisted of the thermodynamic control of products at equilibrium using the lipase CalB as a catalyst. The enzymatic chemo- an...

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Bibliographic Details
Main Authors: Marina A. Ortega-Rojas, José Domingo Rivera-Ramírez, C. Gabriela Ávila-Ortiz, Eusebio Juaristi, Fernando González-Muñoz, Edmundo Castillo, Jaime Escalante
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
lipase promiscuity
aza-Michael addition
stereoselectivity
enantioselectivity
chemoselectivity
solvent engineering
Online Access:https://www.mdpi.com/1420-3049/22/12/2189

Internet

https://www.mdpi.com/1420-3049/22/12/2189

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