One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity

One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity

The use of the solvent engineering has been applied for controlling the resolution of lipase-catalyzed synthesis of β-aminoacids via Michael addition reactions. The strategy consisted of the thermodynamic control of products at equilibrium using the lipase CalB as a catalyst. The enzymatic chemo- an...

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Bibliographic Details
Main Authors:	Marina A. Ortega-Rojas, José Domingo Rivera-Ramírez, C. Gabriela Ávila-Ortiz, Eusebio Juaristi, Fernando González-Muñoz, Edmundo Castillo, Jaime Escalante
Format:	Article
Language:	English
Published:	MDPI AG 2017-12-01
Series:	Molecules
Subjects:	lipase promiscuity aza-Michael addition stereoselectivity enantioselectivity chemoselectivity solvent engineering
Online Access:	https://www.mdpi.com/1420-3049/22/12/2189

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