Notch-Jagged1 signaling and response to bevacizumab therapy in advanced colorectal cancer: A glance to radiomics or back to physiopathology?

Notch-Jagged1 signaling and response to bevacizumab therapy in advanced colorectal cancer: A glance to radiomics or back to physiopathology?

IntroductionThe Notch intracellular domain (NICD) and its ligands Jagged-1(Jag1), Delta-like ligand (DLL-3) and DLL4 play an important role in neoangiogenesis. Previous studies suggest a correlation between the tissue levels of NICD and response to therapy with bevacizumab in colorectal cancer (CRC)...

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Main Authors: Francesca Negri, Lorena Bottarelli, Giuseppe Pedrazzi, Michele Maddalo, Ludovica Leo, Gianluca Milanese, Roberto Sala, Michele Lecchini, Nicoletta Campanini, Cecilia Bozzetti, Andrea Zavani, Gianluca Di Rienzo, Cinzia Azzoni, Enrico Maria Silini, Nicola Sverzellati, Federica Gaiani, Gian Luigi de’ Angelis, Letizia Gnetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
Notch signaling pathway
bevacizumab
colorectal cancer
Jagged-1
therapy resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1132564/full

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