FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability
The development of bioresorbable materials for temporary implantation enables progress in medical technology. Iron (Fe)-based degradable materials are biocompatible and exhibit good mechanical properties, but their degradation rate is low. Aside from alloying with Manganese (Mn), the creation of pha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/185 |
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| author | Jan Tobias Krüger Kay-Peter Hoyer Jingyuan Huang Viviane Filor Rafael Hernan Mateus-Vargas Hilke Oltmanns Jessica Meißner Guido Grundmeier Mirko Schaper |
| author_facet | Jan Tobias Krüger Kay-Peter Hoyer Jingyuan Huang Viviane Filor Rafael Hernan Mateus-Vargas Hilke Oltmanns Jessica Meißner Guido Grundmeier Mirko Schaper |
| author_sort | Jan Tobias Krüger |
| collection | DOAJ |
| description | The development of bioresorbable materials for temporary implantation enables progress in medical technology. Iron (Fe)-based degradable materials are biocompatible and exhibit good mechanical properties, but their degradation rate is low. Aside from alloying with Manganese (Mn), the creation of phases with high electrochemical potential such as silver (Ag) phases to cause the anodic dissolution of FeMn is promising. However, to enable residue-free dissolution, the Ag needs to be modified. This concern is addressed, as FeMn modified with a degradable Ag-Calcium-Lanthanum (AgCaLa) alloy is investigated. The electrochemical properties and the degradation behavior are determined via a static immersion test. The local differences in electrochemical potential increase the degradation rate (low pH values), and the formation of gaps around the Ag phases (neutral pH values) demonstrates the benefit of the strategy. Nevertheless, the formation of corrosion-inhibiting layers avoids an increased degradation rate under a neutral pH value. The complete bioresorption of the material is possible since the phases of the degradable AgCaLa alloy dissolve after the FeMn matrix. Cell viability tests reveal biocompatibility, and the antibacterial activity of the degradation supernatant is observed. Thus, FeMn modified with degradable AgCaLa phases is promising as a bioresorbable material if corrosion-inhibiting layers can be diminished. |
| first_indexed | 2024-03-09T16:15:53Z |
| format | Article |
| id | doaj.art-7b445b40da2d4015a0f6135fca6d61b5 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:15:53Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-7b445b40da2d4015a0f6135fca6d61b52023-11-24T15:49:05ZengMDPI AGJournal of Functional Biomaterials2079-49832022-10-0113418510.3390/jfb13040185FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted BioresorbabilityJan Tobias Krüger0Kay-Peter Hoyer1Jingyuan Huang2Viviane Filor3Rafael Hernan Mateus-Vargas4Hilke Oltmanns5Jessica Meißner6Guido Grundmeier7Mirko Schaper8Materials Science, Paderborn University, Mersinweg 7, 33100 Paderborn, GermanyMaterials Science, Paderborn University, Mersinweg 7, 33100 Paderborn, GermanyTechnical and Macromolecular Chemistry, Paderborn University, Warburger Str. 100, 33098 Paderborn, GermanyDepartment of Veterinary Medicine, Institute of Pharmacology and Toxicology, Freie Universität Berlin, Koserstr. 20, 14195 Berlin, GermanyDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559 Hannover, GermanyDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559 Hannover, GermanyDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559 Hannover, GermanyTechnical and Macromolecular Chemistry, Paderborn University, Warburger Str. 100, 33098 Paderborn, GermanyMaterials Science, Paderborn University, Mersinweg 7, 33100 Paderborn, GermanyThe development of bioresorbable materials for temporary implantation enables progress in medical technology. Iron (Fe)-based degradable materials are biocompatible and exhibit good mechanical properties, but their degradation rate is low. Aside from alloying with Manganese (Mn), the creation of phases with high electrochemical potential such as silver (Ag) phases to cause the anodic dissolution of FeMn is promising. However, to enable residue-free dissolution, the Ag needs to be modified. This concern is addressed, as FeMn modified with a degradable Ag-Calcium-Lanthanum (AgCaLa) alloy is investigated. The electrochemical properties and the degradation behavior are determined via a static immersion test. The local differences in electrochemical potential increase the degradation rate (low pH values), and the formation of gaps around the Ag phases (neutral pH values) demonstrates the benefit of the strategy. Nevertheless, the formation of corrosion-inhibiting layers avoids an increased degradation rate under a neutral pH value. The complete bioresorption of the material is possible since the phases of the degradable AgCaLa alloy dissolve after the FeMn matrix. Cell viability tests reveal biocompatibility, and the antibacterial activity of the degradation supernatant is observed. Thus, FeMn modified with degradable AgCaLa phases is promising as a bioresorbable material if corrosion-inhibiting layers can be diminished.https://www.mdpi.com/2079-4983/13/4/185antibacterial behaviorbiocompatibilitybiomedical applicationbioresorbable metalcorrosioniron alloys |
| spellingShingle | Jan Tobias Krüger Kay-Peter Hoyer Jingyuan Huang Viviane Filor Rafael Hernan Mateus-Vargas Hilke Oltmanns Jessica Meißner Guido Grundmeier Mirko Schaper FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability Journal of Functional Biomaterials antibacterial behavior biocompatibility biomedical application bioresorbable metal corrosion iron alloys |
| title | FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability |
| title_full | FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability |
| title_fullStr | FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability |
| title_full_unstemmed | FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability |
| title_short | FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability |
| title_sort | femn with phases of a degradable ag alloy for residue free and adapted bioresorbability |
| topic | antibacterial behavior biocompatibility biomedical application bioresorbable metal corrosion iron alloys |
| url | https://www.mdpi.com/2079-4983/13/4/185 |
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