Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

Context: Alzheimer’s disease (AD) is the most common form of dementia affecting the aged population and neuroinflammation is one of the most observed AD pathologies. NF-κB is the central regulator of inflammation and inhibitor κB kinase (IKK) is the converging point in NF-κB activation. Celastrol is...

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Bibliographic Details
Main Authors:	Karpagam Veerappan, Sathishkumar Natarajan, Purushoth Ethiraj, Umashankar Vetrivel, Shila Samuel
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-01-01
Series:	Pharmaceutical Biology
Subjects:	alzheimer’s disease neuroinflammation amyloid-β molecular docking admet
Online Access:	http://dx.doi.org/10.1080/13880209.2016.1241809

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