Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA<sub>A</sub> Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor

Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA<sub>A</sub> Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor

The positive allosteric modulators (PAMs) of the α7 nicotinic receptor <i>N</i>-(5-Cl-2-hydroxyphenyl)-<i>N</i>′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and (<i>E</i>)-3-(furan-2-yl)-<i>N</i>-(<i>p</i>-tolyl)-acrylamide (PAM-2) pote...

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Bibliographic Details
Main Authors: Spencer R. Pierce, Allison L. Germann, Sophia Q. Xu, Saumith L. Menon, Marcelo O. Ortells, Hugo R. Arias, Gustav Akk
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomolecules
Subjects:
GABA<sub>A</sub> receptor
α7 nicotinic receptor
modulation
potentiator
allostery
Online Access:https://www.mdpi.com/2218-273X/13/4/698

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