Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan
Abstract We present a single-center retrospective analysis of 228 Japanese patients with peritoneal dialysis, in which we examined whether reduced left ventricular ejection fraction (LVEF) is a risk factor for peritonitis development. Time-dependent multivariable-adjusted Cox proportional hazards mo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49744-4 |
| _version_ | 1797376983366107136 |
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| author | Makoto Yamaguchi Takaaki Obayashi Naoto Kobayashi Naoki Izumi Masaaki Nagai Hironobu Nobata Akimasa Asai Keisuke Kamiya Hirokazu Sugiyama Hiroshi Kinashi Shogo Banno Masahiko Ando Takahiro Imaizumi Yoko Kubo Takayuki Katsuno Takuji Ishimoto Yasuhiko Ito |
| author_facet | Makoto Yamaguchi Takaaki Obayashi Naoto Kobayashi Naoki Izumi Masaaki Nagai Hironobu Nobata Akimasa Asai Keisuke Kamiya Hirokazu Sugiyama Hiroshi Kinashi Shogo Banno Masahiko Ando Takahiro Imaizumi Yoko Kubo Takayuki Katsuno Takuji Ishimoto Yasuhiko Ito |
| author_sort | Makoto Yamaguchi |
| collection | DOAJ |
| description | Abstract We present a single-center retrospective analysis of 228 Japanese patients with peritoneal dialysis, in which we examined whether reduced left ventricular ejection fraction (LVEF) is a risk factor for peritonitis development. Time-dependent multivariable-adjusted Cox proportional hazards models revealed that reduced LVEF (LVEF < 50% vs. preserved LVEF ≥ 50%, hazard ratio (HR) 2.10; 95% confidence interval (CI) 1.16–3.82) was associated with peritonitis. Qualitatively, similar associations with reduced LVEF (< 50%) were observed for enteric peritonitis (adjusted HR 7.68; 95% CI 2.51–23.5) but not for non-enteric peritonitis (adjusted HR 1.15; 95% CI 0.54–2.44). Reduced LVEF is associated with a significantly higher risk of subsequent peritonitis, particularly enteric peritonitis. These results indicate that patients with reduced LVEF may be at risk of enteric peritonitis from bowel sources caused by intestinal involvement due to cardiac dysfunction. |
| first_indexed | 2024-03-08T19:46:25Z |
| format | Article |
| id | doaj.art-7b4656d815244f578270aa029691bd1e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T19:46:25Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7b4656d815244f578270aa029691bd1e2023-12-24T12:19:31ZengNature PortfolioScientific Reports2045-23222023-12-0113111110.1038/s41598-023-49744-4Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in JapanMakoto Yamaguchi0Takaaki Obayashi1Naoto Kobayashi2Naoki Izumi3Masaaki Nagai4Hironobu Nobata5Akimasa Asai6Keisuke Kamiya7Hirokazu Sugiyama8Hiroshi Kinashi9Shogo Banno10Masahiko Ando11Takahiro Imaizumi12Yoko Kubo13Takayuki Katsuno14Takuji Ishimoto15Yasuhiko Ito16Department of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology, Narita Memorial HospitalDepartment of Nephrology, Narita Memorial HospitalDepartment of Nephrology, Narita Memorial HospitalDepartment of Nephrology, Narita Memorial HospitalDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityData Coordinating Center, Department of Advanced Medicine, Nagoya University HospitalData Coordinating Center, Department of Advanced Medicine, Nagoya University HospitalDepartment of Preventive Medicine, Nagoya University Graduate School of MedicineDepartment of Nephrology and Rheumatology, Aichi Medical University Medical CenterDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityAbstract We present a single-center retrospective analysis of 228 Japanese patients with peritoneal dialysis, in which we examined whether reduced left ventricular ejection fraction (LVEF) is a risk factor for peritonitis development. Time-dependent multivariable-adjusted Cox proportional hazards models revealed that reduced LVEF (LVEF < 50% vs. preserved LVEF ≥ 50%, hazard ratio (HR) 2.10; 95% confidence interval (CI) 1.16–3.82) was associated with peritonitis. Qualitatively, similar associations with reduced LVEF (< 50%) were observed for enteric peritonitis (adjusted HR 7.68; 95% CI 2.51–23.5) but not for non-enteric peritonitis (adjusted HR 1.15; 95% CI 0.54–2.44). Reduced LVEF is associated with a significantly higher risk of subsequent peritonitis, particularly enteric peritonitis. These results indicate that patients with reduced LVEF may be at risk of enteric peritonitis from bowel sources caused by intestinal involvement due to cardiac dysfunction.https://doi.org/10.1038/s41598-023-49744-4 |
| spellingShingle | Makoto Yamaguchi Takaaki Obayashi Naoto Kobayashi Naoki Izumi Masaaki Nagai Hironobu Nobata Akimasa Asai Keisuke Kamiya Hirokazu Sugiyama Hiroshi Kinashi Shogo Banno Masahiko Ando Takahiro Imaizumi Yoko Kubo Takayuki Katsuno Takuji Ishimoto Yasuhiko Ito Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan Scientific Reports |
| title | Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan |
| title_full | Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan |
| title_fullStr | Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan |
| title_full_unstemmed | Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan |
| title_short | Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan |
| title_sort | association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis a single center retrospective cohort study in japan |
| url | https://doi.org/10.1038/s41598-023-49744-4 |
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