Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients
Abstract The objective of this study was to assess the prognostic value of asphericity (ASP) and standardized uptake ratio (SUR) in cervical cancer patients. Retrospective analysis was performed on a group of 508 (aged 55 ± 12 years) previously untreated cervical cancer patients. All patients underw...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-35191-8 |
| _version_ | 1827939978261299200 |
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| author | Paulina Cegla Frank Hofheinz Ewa Burchardt Rafał Czepczyński Anna Kubiak Jörg van den Hoff Pavel Nikulin Agnieszka Bos-Liedke Andrzej Roszak Witold Cholewinski |
| author_facet | Paulina Cegla Frank Hofheinz Ewa Burchardt Rafał Czepczyński Anna Kubiak Jörg van den Hoff Pavel Nikulin Agnieszka Bos-Liedke Andrzej Roszak Witold Cholewinski |
| author_sort | Paulina Cegla |
| collection | DOAJ |
| description | Abstract The objective of this study was to assess the prognostic value of asphericity (ASP) and standardized uptake ratio (SUR) in cervical cancer patients. Retrospective analysis was performed on a group of 508 (aged 55 ± 12 years) previously untreated cervical cancer patients. All patients underwent a pretreatment [18F]FDG PET/CT study to assess the severity of the disease. The metabolic tumor volume (MTV) of the cervical cancer was delineated with an adaptive threshold method. For the resulting ROIs the maximum standardized uptake value (SUVmax) was measured. In addition, ASP and SUR were determined as previously described. Univariate Cox regression and Kaplan–Meier analysis with respect to event free survival (EFS), overall survival (OS), freedom from distant metastasis (FFDM) and locoregional control (LRC) was performed. Additionally, a multivariate Cox regression including clinically relevant parameters was performed. In the survival analysis, MTV and ASP were shown to be prognostic factors for all investigated endpoints. Tumor metabolism quantified with the SUVmax was not prognostic for any of the endpoints (p > 0.2). The SUR did not reach statistical significance either (p = 0.1, 0.25, 0.066, 0.053, respectively). In the multivariate analysis, the ASP remained a significant factor for EFS and LRC, while MTV was a significant factor for FFDM, indicating their independent prognostic value for the respective endpoints. The alternative parameter ASP has the potential to improve the prognostic value of [18F]FDG PET/CT for event-free survival and locoregional control in radically treated cervical cancer patients. |
| first_indexed | 2024-03-13T09:02:44Z |
| format | Article |
| id | doaj.art-7b477d97d6854085b2b3349af1a10370 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T09:02:44Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7b477d97d6854085b2b3349af1a103702023-05-28T11:14:43ZengNature PortfolioScientific Reports2045-23222023-05-011311710.1038/s41598-023-35191-8Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patientsPaulina Cegla0Frank Hofheinz1Ewa Burchardt2Rafał Czepczyński3Anna Kubiak4Jörg van den Hoff5Pavel Nikulin6Agnieszka Bos-Liedke7Andrzej Roszak8Witold Cholewinski9Department of Nuclear Medicine, Greater Poland Cancer CentreHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer ResearchDepartment of Electroradiology, Poznan Univeristy of Medical ScienceDepartment of Endocrinology, Metabolism and Internal Disease, Poznan University of Medical ScienceGreater Poland Cancer Registry, Greater Poland Cancer CentreHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer ResearchHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer ResearchDepartment of Biomedical Physics, Adam Mickiewicz UniversityDepartment of Electroradiology, Poznan Univeristy of Medical ScienceDepartment of Nuclear Medicine, Greater Poland Cancer CentreAbstract The objective of this study was to assess the prognostic value of asphericity (ASP) and standardized uptake ratio (SUR) in cervical cancer patients. Retrospective analysis was performed on a group of 508 (aged 55 ± 12 years) previously untreated cervical cancer patients. All patients underwent a pretreatment [18F]FDG PET/CT study to assess the severity of the disease. The metabolic tumor volume (MTV) of the cervical cancer was delineated with an adaptive threshold method. For the resulting ROIs the maximum standardized uptake value (SUVmax) was measured. In addition, ASP and SUR were determined as previously described. Univariate Cox regression and Kaplan–Meier analysis with respect to event free survival (EFS), overall survival (OS), freedom from distant metastasis (FFDM) and locoregional control (LRC) was performed. Additionally, a multivariate Cox regression including clinically relevant parameters was performed. In the survival analysis, MTV and ASP were shown to be prognostic factors for all investigated endpoints. Tumor metabolism quantified with the SUVmax was not prognostic for any of the endpoints (p > 0.2). The SUR did not reach statistical significance either (p = 0.1, 0.25, 0.066, 0.053, respectively). In the multivariate analysis, the ASP remained a significant factor for EFS and LRC, while MTV was a significant factor for FFDM, indicating their independent prognostic value for the respective endpoints. The alternative parameter ASP has the potential to improve the prognostic value of [18F]FDG PET/CT for event-free survival and locoregional control in radically treated cervical cancer patients.https://doi.org/10.1038/s41598-023-35191-8 |
| spellingShingle | Paulina Cegla Frank Hofheinz Ewa Burchardt Rafał Czepczyński Anna Kubiak Jörg van den Hoff Pavel Nikulin Agnieszka Bos-Liedke Andrzej Roszak Witold Cholewinski Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients Scientific Reports |
| title | Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients |
| title_full | Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients |
| title_fullStr | Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients |
| title_full_unstemmed | Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients |
| title_short | Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients |
| title_sort | asphericity derived from 18f fdg pet as a new prognostic parameter in cervical cancer patients |
| url | https://doi.org/10.1038/s41598-023-35191-8 |
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