Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil
The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high pr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2003-11-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/9/11/03-0193_article |
| _version_ | 1819237096271904768 |
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| author | Márcio Antonio Moreira Galvão J. Stephen Dumler Cláudio Lísias Mafra Simone Berger Calic Chequer Buffe Chamone Gracco Cesarino Filho Juan Pablo Olano David H. Walker |
| author_facet | Márcio Antonio Moreira Galvão J. Stephen Dumler Cláudio Lísias Mafra Simone Berger Calic Chequer Buffe Chamone Gracco Cesarino Filho Juan Pablo Olano David H. Walker |
| author_sort | Márcio Antonio Moreira Galvão |
| collection | DOAJ |
| description | The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests. |
| first_indexed | 2024-12-23T13:14:54Z |
| format | Article |
| id | doaj.art-7b47f37e371749dea6f6a45d6000d26b |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-23T13:14:54Z |
| publishDate | 2003-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-7b47f37e371749dea6f6a45d6000d26b2022-12-21T17:45:37ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-11-019111402140510.3201/eid0911.030193Fatal Spotted Fever Rickettsiosis, Minas Gerais, BrazilMárcio Antonio Moreira GalvãoJ. Stephen DumlerCláudio Lísias MafraSimone Berger CalicChequer Buffe ChamoneGracco Cesarino FilhoJuan Pablo OlanoDavid H. WalkerThe emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests.https://wwwnc.cdc.gov/eid/article/9/11/03-0193_articleBrazil |
| spellingShingle | Márcio Antonio Moreira Galvão J. Stephen Dumler Cláudio Lísias Mafra Simone Berger Calic Chequer Buffe Chamone Gracco Cesarino Filho Juan Pablo Olano David H. Walker Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil Emerging Infectious Diseases Brazil |
| title | Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil |
| title_full | Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil |
| title_fullStr | Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil |
| title_full_unstemmed | Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil |
| title_short | Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil |
| title_sort | fatal spotted fever rickettsiosis minas gerais brazil |
| topic | Brazil |
| url | https://wwwnc.cdc.gov/eid/article/9/11/03-0193_article |
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