Characterization of the Secreted Acid Phosphatase SapS Reveals a Novel Virulence Factor of <i>Staphylococcus aureus</i> That Contributes to Survival and Virulence in Mice

Characterization of the Secreted Acid Phosphatase SapS Reveals a Novel Virulence Factor of <i>Staphylococcus aureus</i> That Contributes to Survival and Virulence in Mice

<i>Staphylococcus aureus</i> possesses a large arsenal of immune-modulating factors, enabling it to bypass the immune system’s response. Here, we demonstrate that the acid phosphatase SapS is secreted during macrophage infection and promotes its intracellular survival in this type of imm...

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Bibliographic Details
Main Authors: Nour Ahmad-Mansour, Mohamed Ibrahem Elhawy, Sylvaine Huc-Brandt, Nadhuma Youssouf, Linda Pätzold, Marianne Martin, Noran Abdel-Wadood, Ahmad Aljohmani, Madjid Morsli, Gabriela Krasteva-Christ, Sören L. Becker, Daniela Yildiz, Jean-Philippe Lavigne, Laila Gannoun-Zaki, Markus Bischoff, Virginie Molle
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Staphylococcus aureus</i>
acid phosphatase
SapS
macrophage survival
virulence
inflammatory response
Online Access:https://www.mdpi.com/1422-0067/23/22/14031

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